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Decreased activity in the reward network of chronic insomnia patients

In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in c...

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Autores principales: Motomura, Yuki, Katsunuma, Ruri, Ayabe, Naoko, Oba, Kentaro, Terasawa, Yuri, Kitamura, Shingo, Moriguchi, Yoshiya, Hida, Akiko, Kamei, Yuichi, Mishima, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878866/
https://www.ncbi.nlm.nih.gov/pubmed/33574355
http://dx.doi.org/10.1038/s41598-020-79989-2
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author Motomura, Yuki
Katsunuma, Ruri
Ayabe, Naoko
Oba, Kentaro
Terasawa, Yuri
Kitamura, Shingo
Moriguchi, Yoshiya
Hida, Akiko
Kamei, Yuichi
Mishima, Kazuo
author_facet Motomura, Yuki
Katsunuma, Ruri
Ayabe, Naoko
Oba, Kentaro
Terasawa, Yuri
Kitamura, Shingo
Moriguchi, Yoshiya
Hida, Akiko
Kamei, Yuichi
Mishima, Kazuo
author_sort Motomura, Yuki
collection PubMed
description In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli.
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spelling pubmed-78788662021-02-12 Decreased activity in the reward network of chronic insomnia patients Motomura, Yuki Katsunuma, Ruri Ayabe, Naoko Oba, Kentaro Terasawa, Yuri Kitamura, Shingo Moriguchi, Yoshiya Hida, Akiko Kamei, Yuichi Mishima, Kazuo Sci Rep Article In modern society, many people have insomnia. Chronic insomnia has been noted as a risk factor for depression. However, there are few functional imaging studies of the brain on affective functions in chronic insomnia. This study aimed to investigate brain activities induced by emotional stimuli in chronic insomnia patients. Fifteen patients with primary insomnia and 30 age and gender matched healthy controls participated in this study. Both groups were presented images of fearful, happy, and neutral expressions consciously and non-consciously while undergoing MRI to compare the activity in regions of the brain responsible for emotions. Conscious presentation of the Happy-Neutral contrast showed significantly lower activation in the right orbitofrontal cortex of patients compared to healthy controls. The Happy-Neutral contrast presented in a non-conscious manner resulted in significantly lower activation of the ventral striatum, right insula, putamen, orbitofrontal cortex and ventral tegmental area in patients compared to healthy controls. Our findings revealed that responsiveness to positive emotional stimuli were decreased in insomniac patients. Specifically, brain networks associated with rewards and processing positive emotions showed decreased responsiveness to happy emotions especially for non-conscious image. The magnitude of activity in these areas also correlated with severity of insomnia, even after controlling for depression scale scores. These findings suggest that insomnia induces an affective functional disorder through an underlying mechanism of decreased sensitivity in the regions of the brain responsible for emotions and rewards to positive emotional stimuli. Nature Publishing Group UK 2021-02-11 /pmc/articles/PMC7878866/ /pubmed/33574355 http://dx.doi.org/10.1038/s41598-020-79989-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Motomura, Yuki
Katsunuma, Ruri
Ayabe, Naoko
Oba, Kentaro
Terasawa, Yuri
Kitamura, Shingo
Moriguchi, Yoshiya
Hida, Akiko
Kamei, Yuichi
Mishima, Kazuo
Decreased activity in the reward network of chronic insomnia patients
title Decreased activity in the reward network of chronic insomnia patients
title_full Decreased activity in the reward network of chronic insomnia patients
title_fullStr Decreased activity in the reward network of chronic insomnia patients
title_full_unstemmed Decreased activity in the reward network of chronic insomnia patients
title_short Decreased activity in the reward network of chronic insomnia patients
title_sort decreased activity in the reward network of chronic insomnia patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878866/
https://www.ncbi.nlm.nih.gov/pubmed/33574355
http://dx.doi.org/10.1038/s41598-020-79989-2
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