Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

Aspartate transcarbamoylase (ATC), an essential enzyme for de novo pyrimidine biosynthesis, is uniquely regulated in plants by feedback inhibition of uridine 5-monophosphate (UMP). Despite its importance in plant growth, the structure of this UMP-controlled ATC and the regulatory mechanism remain un...

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Detalles Bibliográficos
Autores principales: Bellin, Leo, Del Caño-Ochoa, Francisco, Velázquez-Campoy, Adrián, Möhlmann, Torsten, Ramón-Maiques, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878868/
https://www.ncbi.nlm.nih.gov/pubmed/33574254
http://dx.doi.org/10.1038/s41467-021-21165-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878868/
https://www.ncbi.nlm.nih.gov/pubmed/33574254
http://dx.doi.org/10.1038/s41467-021-21165-9

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