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A retrospective study of hypofractionated radiotherapy for keloids in 100 cases

At present, the consensus on the best treatment for keloids is the combination of clinical and surgical therapies, if necessary, associated with adjuvant radiotherapy like brachytherapy. Whereas, the uniform scheme of radiotherapy in keloids is unclear. Here, we conducting a retrospective analysis t...

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Autores principales: Wen, Ping, Wang, Taifang, Zhou, Yueling, Yu, Yue, Wu, Chunli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878871/
https://www.ncbi.nlm.nih.gov/pubmed/33574426
http://dx.doi.org/10.1038/s41598-021-83255-4
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author Wen, Ping
Wang, Taifang
Zhou, Yueling
Yu, Yue
Wu, Chunli
author_facet Wen, Ping
Wang, Taifang
Zhou, Yueling
Yu, Yue
Wu, Chunli
author_sort Wen, Ping
collection PubMed
description At present, the consensus on the best treatment for keloids is the combination of clinical and surgical therapies, if necessary, associated with adjuvant radiotherapy like brachytherapy. Whereas, the uniform scheme of radiotherapy in keloids is unclear. Here, we conducting a retrospective analysis to assess the efficacy and safety of a specific treatment regimen (20 Gy in 5 fractions) in keloid patients. We retrospectively analysed the medical records of keloid patients receiving auxiliary postoperative radiotherapy (PORT) treatment from 2009 to 2019. The patients were treated with the hypofractionation method of 20 Gy in 5 fractions. We compared the local control rate and complications, using the chi-square test and logistic regression analyses. After screening, we identified 100 keloid patients in this study, with a median follow-up of 59 months. In this study, the overall local control rate of keloid lesions was 84.8%. After multivariate analyses (primary keloid or not, family history, interval from surgery to irradiation and site), our research showed that primary keloid, site and interval from surgery to irradiation were significantly related to recurrence. Acute radiation injury and late radiation injury accounted for 3% (erythema) and 1% (skin sclerosis) of the total cases, respectively. Our results indicate that a postoperative hypofractionation with radiation dose of 20 Gy in 5 fractions may be effective, easy to accept and safe for keloid patients.
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spelling pubmed-78788712021-02-12 A retrospective study of hypofractionated radiotherapy for keloids in 100 cases Wen, Ping Wang, Taifang Zhou, Yueling Yu, Yue Wu, Chunli Sci Rep Article At present, the consensus on the best treatment for keloids is the combination of clinical and surgical therapies, if necessary, associated with adjuvant radiotherapy like brachytherapy. Whereas, the uniform scheme of radiotherapy in keloids is unclear. Here, we conducting a retrospective analysis to assess the efficacy and safety of a specific treatment regimen (20 Gy in 5 fractions) in keloid patients. We retrospectively analysed the medical records of keloid patients receiving auxiliary postoperative radiotherapy (PORT) treatment from 2009 to 2019. The patients were treated with the hypofractionation method of 20 Gy in 5 fractions. We compared the local control rate and complications, using the chi-square test and logistic regression analyses. After screening, we identified 100 keloid patients in this study, with a median follow-up of 59 months. In this study, the overall local control rate of keloid lesions was 84.8%. After multivariate analyses (primary keloid or not, family history, interval from surgery to irradiation and site), our research showed that primary keloid, site and interval from surgery to irradiation were significantly related to recurrence. Acute radiation injury and late radiation injury accounted for 3% (erythema) and 1% (skin sclerosis) of the total cases, respectively. Our results indicate that a postoperative hypofractionation with radiation dose of 20 Gy in 5 fractions may be effective, easy to accept and safe for keloid patients. Nature Publishing Group UK 2021-02-11 /pmc/articles/PMC7878871/ /pubmed/33574426 http://dx.doi.org/10.1038/s41598-021-83255-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wen, Ping
Wang, Taifang
Zhou, Yueling
Yu, Yue
Wu, Chunli
A retrospective study of hypofractionated radiotherapy for keloids in 100 cases
title A retrospective study of hypofractionated radiotherapy for keloids in 100 cases
title_full A retrospective study of hypofractionated radiotherapy for keloids in 100 cases
title_fullStr A retrospective study of hypofractionated radiotherapy for keloids in 100 cases
title_full_unstemmed A retrospective study of hypofractionated radiotherapy for keloids in 100 cases
title_short A retrospective study of hypofractionated radiotherapy for keloids in 100 cases
title_sort retrospective study of hypofractionated radiotherapy for keloids in 100 cases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878871/
https://www.ncbi.nlm.nih.gov/pubmed/33574426
http://dx.doi.org/10.1038/s41598-021-83255-4
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