Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice

Severe skeletal alterations are common symptoms in patients with mucolipidosis type II (MLII), a rare lysosomal storage disorder of childhood. We have previously reported that progressive bone loss in a mouse model for MLII is caused by an increased number of bone-resorbing osteoclasts, which is acc...

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Detalles Bibliográficos
Autores principales: Westermann, Lena Marie, Baranowsky, Anke, Di Lorenzo, Giorgia, Danyukova, Tatyana, Soul, Jamie, Schwartz, Jean-Marc, Hendrickx, Gretl, Amling, Michael, Rose-John, Stefan, Garbers, Christoph, Schinke, Thorsten, Pohl, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878873/
https://www.ncbi.nlm.nih.gov/pubmed/33574442
http://dx.doi.org/10.1038/s41598-021-82802-3

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