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Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation
Long natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming majority o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878882/ https://www.ncbi.nlm.nih.gov/pubmed/33574420 http://dx.doi.org/10.1038/s41598-021-83190-4 |
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author | Korneev, Sergei Garaliene, Jekaterina Taylor, Gabriella Kemenes, Ildikó Kemenes, György |
author_facet | Korneev, Sergei Garaliene, Jekaterina Taylor, Gabriella Kemenes, Ildikó Kemenes, György |
author_sort | Korneev, Sergei |
collection | PubMed |
description | Long natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming majority of long NATs remain unclear. Here we report on the characterization of a novel molluscan nitric oxide synthase (NOS)-related long non-coding NAT (Lym-NOS1AS). This NAT is spliced and polyadenylated and is transcribed from the non-template strand of the Lym-NOS1 gene. We demonstrate that the Lym-NOS1AS is co-expressed with the sense Lym-NOS1 mRNA in a key neuron of memory network. Also, we report that the Lym-NOS1AS is temporally and spatially regulated by one-trial conditioning leading to long term memory (LTM) formation. Specifically, in the cerebral, but not in the buccal ganglia, the temporal pattern of changes in Lym-NOS1AS expression after training correlates with the alteration of memory lapse and non-lapse periods. Our data suggest that the Lym-NOS1AS plays a role in the consolidation of nitric oxide-dependent LTM. |
format | Online Article Text |
id | pubmed-7878882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78788822021-02-12 Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation Korneev, Sergei Garaliene, Jekaterina Taylor, Gabriella Kemenes, Ildikó Kemenes, György Sci Rep Article Long natural antisense transcripts (NATs) have been demonstrated in significant numbers in a variety of eukaryotic organisms. They are particularly prevalent in the nervous system suggesting their importance in neural functions. However, the precise physiological roles of the overwhelming majority of long NATs remain unclear. Here we report on the characterization of a novel molluscan nitric oxide synthase (NOS)-related long non-coding NAT (Lym-NOS1AS). This NAT is spliced and polyadenylated and is transcribed from the non-template strand of the Lym-NOS1 gene. We demonstrate that the Lym-NOS1AS is co-expressed with the sense Lym-NOS1 mRNA in a key neuron of memory network. Also, we report that the Lym-NOS1AS is temporally and spatially regulated by one-trial conditioning leading to long term memory (LTM) formation. Specifically, in the cerebral, but not in the buccal ganglia, the temporal pattern of changes in Lym-NOS1AS expression after training correlates with the alteration of memory lapse and non-lapse periods. Our data suggest that the Lym-NOS1AS plays a role in the consolidation of nitric oxide-dependent LTM. Nature Publishing Group UK 2021-02-11 /pmc/articles/PMC7878882/ /pubmed/33574420 http://dx.doi.org/10.1038/s41598-021-83190-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Korneev, Sergei Garaliene, Jekaterina Taylor, Gabriella Kemenes, Ildikó Kemenes, György Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation |
title | Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation |
title_full | Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation |
title_fullStr | Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation |
title_full_unstemmed | Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation |
title_short | Time dependent differential regulation of a novel long non-coding natural antisense RNA during long-term memory formation |
title_sort | time dependent differential regulation of a novel long non-coding natural antisense rna during long-term memory formation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878882/ https://www.ncbi.nlm.nih.gov/pubmed/33574420 http://dx.doi.org/10.1038/s41598-021-83190-4 |
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