Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2

An efficient treatment against a COVID-19 disease, caused by the novel coronavirus SARS-CoV-2 (CoV2), remains a challenge. The papain-like protease (PL(pro)) from the human coronavirus is a protease that plays a critical role in virus replication. Moreover, CoV2 uses this enzyme to modulate the host...

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Detalles Bibliográficos
Autores principales: Weglarz-Tomczak, Ewelina, Tomczak, Jakub M., Talma, Michał, Burda-Grabowska, Małgorzata, Giurg, Mirosław, Brul, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878891/
https://www.ncbi.nlm.nih.gov/pubmed/33574416
http://dx.doi.org/10.1038/s41598-021-83229-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878891/
https://www.ncbi.nlm.nih.gov/pubmed/33574416
http://dx.doi.org/10.1038/s41598-021-83229-6

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