Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks

A promotional role for androgen receptor (AR) signaling in hepatocellular carcinogenesis is emerging. In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis. However, pharmacologic anti-androgen therapy...

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Detalles Bibliográficos
Autores principales: Helms, Timothy H., Mullins, Riley D., Thomas-Ahner, Jennifer M., Kulp, Samuel K., Campbell, Moray J., Lucas, Fabienne, Schmidt, Nathan, LeMoine, Dana M., Getaneh, Surafel, Xie, Zhiliang, Phelps, Mitch A., Clinton, Steven K., Coss, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878907/
https://www.ncbi.nlm.nih.gov/pubmed/33574348
http://dx.doi.org/10.1038/s41598-021-82252-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878907/
https://www.ncbi.nlm.nih.gov/pubmed/33574348
http://dx.doi.org/10.1038/s41598-021-82252-x

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