Cargando…

Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks

A promotional role for androgen receptor (AR) signaling in hepatocellular carcinogenesis is emerging. In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis. However, pharmacologic anti-androgen therapy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Helms, Timothy H., Mullins, Riley D., Thomas-Ahner, Jennifer M., Kulp, Samuel K., Campbell, Moray J., Lucas, Fabienne, Schmidt, Nathan, LeMoine, Dana M., Getaneh, Surafel, Xie, Zhiliang, Phelps, Mitch A., Clinton, Steven K., Coss, Christopher C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878907/ https://www.ncbi.nlm.nih.gov/pubmed/33574348 http://dx.doi.org/10.1038/s41598-021-82252-x

Ejemplares similares

Androgen receptor concentrations in the diethylnitrosamine model of hepatic carcinogenesis.
por: Bannister, P., et al.
Publicado: (1986)

Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino‐terminal domain
por: Hua, Yaping, et al.
Publicado: (2018)

Metformin inhibits early stage diethylnitrosamine-induced hepatocarcinogenesis in rats
por: JO, WOORI, et al.
Publicado: (2016)

Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR N-C dimerization and AR-coactivators interaction
por: Xu, Defeng, et al.
Publicado: (2017)

Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents
por: Singh, Deepika, et al.
Publicado: (2021)

Stilbene Induced Inhibition of Androgen Receptor Dimerization: Implications for AR and ARΔLBD-Signalling in Human Prostate Cancer Cells
por: Streicher, Wolfgang, et al.
Publicado: (2014)

Antiandrogen-Equipped Histone Deacetylase Inhibitors Selectively Inhibit Androgen Receptor (AR) and AR-Splice Variant (AR-SV) in Castration-Resistant Prostate Cancer (CRPC)
por: Chandrasekaran, Balaji, et al.
Publicado: (2023)

β‐Catenin (Ctnnb1) Gene Mutations in Diethylnitrosamine (DEN)‐induced Liver Tumors in Male F344 Rats
por: Yamada, Yasuhiro, et al.
Publicado: (1999)

Constitutively Active Androgen Receptor in Hepatocellular Carcinoma
por: Montgomery, Emma J., et al.
Publicado: (2022)

The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN)
por: Gao, Jianlong, et al.
Publicado: (2018)

Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice
por: Chen, Jinbiao, et al.
Publicado: (2018)

Calotropis gigantea stem bark extracts inhibit liver cancer induced by diethylnitrosamine
por: Sawong, Suphunwadee, et al.
Publicado: (2022)

Racial Differences in Androgen Receptor (AR) and AR Splice Variants (AR-SVs) Expression in Treatment-Naïve Androgen-Dependent Prostate Cancer
por: Khan, Farhan, et al.
Publicado: (2023)

Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
por: Claessens, Frank, et al.
Publicado: (2008)

Therapeutic targeting of the androgen receptor (AR) and AR variants in prostate cancer
por: Narayanan, Ramesh
Publicado: (2020)

The MYC axis in advanced prostate cancer is impacted through concurrent targeting of ERβ and AR using a novel ERβ-selective ligand alongside Enzalutamide
por: Gray, Jaimie S., et al.
Publicado: (2023)

SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer
por: Ding, Mao, et al.
Publicado: (2020)

Se-Methylselenocysteine Alleviates Liver Injury in Diethylnitrosamine (DEN)-Induced Hepatocellular Carcinoma Rat Model by Reducing Liver Enzymes, Inhibiting Angiogenesis, and Suppressing Nitric Oxide (NO)/Nitric Oxide Synthase (NOS) Signaling Pathway
por: Ding, Jun, et al.
Publicado: (2021)

An iron-deficient diet prevents alcohol- or diethylnitrosamine-induced acute hepatotoxicity in mice by inhibiting ferroptosis
por: Gao, Zelong, et al.
Publicado: (2022)

Identification of an AR Mutation-Negative Class of Androgen Insensitivity by Determining Endogenous AR Activity
por: Hornig, N. C., et al.
Publicado: (2016)

Population Pharmacokinetic Analysis from First-in-Human Data for HDAC Inhibitor, REC-2282 (AR-42), in Patients with Solid Tumors and Hematologic Malignancies: A Case Study for Evaluating Flat vs. Body Size Normalized Dosing
por: Liva, Sophia, et al.
Publicado: (2021)

Amelioration of diethylnitrosamine (DEN)-induced hepatocellular carcinogenesis in animal models via knockdown oxidative stress and proinflammatory markers by Madhuca longifolia embedded silver nanoparticles
por: Singh, Deepika, et al.
Publicado: (2018)

Inhibition by β‐Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure
por: Furukawa, Fumio, et al.
Publicado: (1999)

Gehua Jiecheng Decoction Inhibits Diethylnitrosamine-Induced Hepatocellular Carcinoma in Mice by Improving Tumor Immunosuppression Microenvironment
por: Cheng, Changpei, et al.
Publicado: (2020)

ULK1 Depletion Protects Mice from Diethylnitrosamine-Induced Hepatocarcinogenesis by Promoting Apoptosis and Inhibiting Autophagy
por: Duan, Ting, et al.
Publicado: (2023)

SAT021 Development Of Niclosamide Analogs For Treatment Of Androgen Receptor Positive Hepatocellular Carcinoma
por: Jordan Montgomery, Emma, et al.
Publicado: (2023)

A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo
por: Zhao, Lijie, et al.
Publicado: (2020)

Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
por: Phelps, Mitch, et al.
Publicado: (2016)

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis
por: Krupenko, Natalia I., et al.
Publicado: (2021)

Regulation of AR mRNA translation in response to acute AR pathway inhibition
por: Somasekharan, Syam Prakash, et al.
Publicado: (2021)

Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling
por: Saxena, Neetu, et al.
Publicado: (2021)

Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans
por: Castillo, Alyssa Marie M., et al.
Publicado: (2021)

Detection of androgen receptor (AR) and AR-V7 in small cell prostate carcinoma: Diagnostic and therapeutic implications
por: Zhao, Pei, et al.
Publicado: (2019)

Beta-carotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine.
por: Sarkar, A., et al.
Publicado: (1997)

Resveratrol Down-Regulates Myosin Light Chain Kinase, Induces Apoptosis and Inhibits Diethylnitrosamine-Induced Liver Tumorigenesis in Rats
por: Zhang, Xiao-Lin, et al.
Publicado: (2013)

Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation
por: Shang, Na, et al.
Publicado: (2018)

Combining Crocin and Sorafenib Improves Their Tumor-Inhibiting Effects in a Rat Model of Diethylnitrosamine-Induced Cirrhotic-Hepatocellular Carcinoma
por: Awad, Basma, et al.
Publicado: (2023)

The Individualized Diet and Exercise Adherence Pilot Trial (IDEA-P) in prostate cancer patients undergoing androgen deprivation therapy: study protocol for a randomized controlled trial
por: Focht, Brian C, et al.
Publicado: (2014)

Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines
por: Ramamurthy, Vidya P., et al.
Publicado: (2014)

SAT005 Effect Of OSU-ERβ-12, A Carborane-based ERβ-selective Agonist, On Hepatic Fibrosis And NASH
por: Kumar, Pankaj, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eg0qsb1sj6iivh8aot75jn2fr5