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Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage
Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878909/ https://www.ncbi.nlm.nih.gov/pubmed/33574373 http://dx.doi.org/10.1038/s41598-021-82748-6 |
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author | Wikström, Sverre Hussein, Ghada Lingroth Karlsson, Annika Lindh, Christian H. Bornehag, Carl-Gustaf |
author_facet | Wikström, Sverre Hussein, Ghada Lingroth Karlsson, Annika Lindh, Christian H. Bornehag, Carl-Gustaf |
author_sort | Wikström, Sverre |
collection | PubMed |
description | Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed within the Swedish SELMA pregnancy cohort. Seventy-eight women with non-recurrent first trimester miscarriage were included and 1449 women were available as live birth controls. Eight PFASs were measured in first trimester serum. A doubling of perfluorooctanoic acid (PFOA) exposure, corresponding to an inter-quartile increase, was associated with an odds ratio (95%CI) for miscarriage of 1.48 (1.09–2.01) when adjusting for parity, age and smoking. Analyses per quartiles of PFOA exposure indicated a monotonic dose response association with miscarriage. A similar, but not significant, pattern was observed for perfluorononanoic acid (PFNA). For other PFAS, there were no associations with miscarriage. We have previously shown associations between early pregnancy PFAS exposures and preeclampsia, as well as lower birth weight. Now we report an association between PFOA and miscarriage within the same cohort, which may suggest shared but unknown mechanisms. The study can only represent a period of early placentation and clinical pregnancy loss during the second half of the first trimester. |
format | Online Article Text |
id | pubmed-7878909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78789092021-02-12 Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage Wikström, Sverre Hussein, Ghada Lingroth Karlsson, Annika Lindh, Christian H. Bornehag, Carl-Gustaf Sci Rep Article Many first trimester sporadic miscarriages are unexplained and the role of environmental exposures is unknown. The present aim was to study if levels of Perfluoroalkyl substances (PFASs) in early pregnancy are associated with unexplained, sporadic first trimester miscarriage. The study was performed within the Swedish SELMA pregnancy cohort. Seventy-eight women with non-recurrent first trimester miscarriage were included and 1449 women were available as live birth controls. Eight PFASs were measured in first trimester serum. A doubling of perfluorooctanoic acid (PFOA) exposure, corresponding to an inter-quartile increase, was associated with an odds ratio (95%CI) for miscarriage of 1.48 (1.09–2.01) when adjusting for parity, age and smoking. Analyses per quartiles of PFOA exposure indicated a monotonic dose response association with miscarriage. A similar, but not significant, pattern was observed for perfluorononanoic acid (PFNA). For other PFAS, there were no associations with miscarriage. We have previously shown associations between early pregnancy PFAS exposures and preeclampsia, as well as lower birth weight. Now we report an association between PFOA and miscarriage within the same cohort, which may suggest shared but unknown mechanisms. The study can only represent a period of early placentation and clinical pregnancy loss during the second half of the first trimester. Nature Publishing Group UK 2021-02-11 /pmc/articles/PMC7878909/ /pubmed/33574373 http://dx.doi.org/10.1038/s41598-021-82748-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wikström, Sverre Hussein, Ghada Lingroth Karlsson, Annika Lindh, Christian H. Bornehag, Carl-Gustaf Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage |
title | Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage |
title_full | Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage |
title_fullStr | Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage |
title_full_unstemmed | Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage |
title_short | Exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage |
title_sort | exposure to perfluoroalkyl substances in early pregnancy and risk of sporadic first trimester miscarriage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878909/ https://www.ncbi.nlm.nih.gov/pubmed/33574373 http://dx.doi.org/10.1038/s41598-021-82748-6 |
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