Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met

Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized and evaluated for c-Met inhibitory potential and anticancer effect. The inhibitory activi...

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Detalles Bibliográficos
Autores principales: Damghani, Tahereh, Moosavi, Fatemeh, Khoshneviszadeh, Mehdi, Mortazavi, Motahareh, Pirhadi, Somayeh, Kayani, Zahra, Saso, Luciano, Edraki, Najmeh, Firuzi, Omidreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878917/
https://www.ncbi.nlm.nih.gov/pubmed/33574356
http://dx.doi.org/10.1038/s41598-021-83069-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878917/
https://www.ncbi.nlm.nih.gov/pubmed/33574356
http://dx.doi.org/10.1038/s41598-021-83069-4

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