Cargando…

Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met

Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized and evaluated for c-Met inhibitory potential and anticancer effect. The inhibitory activi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Damghani, Tahereh, Moosavi, Fatemeh, Khoshneviszadeh, Mehdi, Mortazavi, Motahareh, Pirhadi, Somayeh, Kayani, Zahra, Saso, Luciano, Edraki, Najmeh, Firuzi, Omidreza
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878917/ https://www.ncbi.nlm.nih.gov/pubmed/33574356 http://dx.doi.org/10.1038/s41598-021-83069-4

Ejemplares similares

Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
por: Mortazavi, Motahareh, et al.
Publicado: (2023)

Study of the anticancer effect of new quinazolinone hydrazine derivatives as receptor tyrosine kinase inhibitors
por: Mortazavi, Motahareh, et al.
Publicado: (2022)

Phenanthrotriazine Derivatives Containing Arylidine Hydrazone Moieties as Novel Potential c-Met Inhibitors with Anticancer Effect
por: Edraki, Najmeh, et al.
Publicado: (2021)

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study
por: Shahraki, Omolbanin, et al.
Publicado: (2017)

5-Oxo-hexahydroquinoline Derivatives and Their Tetrahydroquinoline Counterparts as Multidrug Resistance Reversal Agents
por: Shahraki, Omolbanin, et al.
Publicado: (2020)

Design and Synthesis of Novel 1-hydroxy-2,4,5-triaryl Imidazole Derivatives as Anti-cytokine Agents
por: Haghighijoo, Zahra, et al.
Publicado: (2020)

Novel Cytotoxic Phenanthro-triazine-3-thiol Derivatives as Potential DNA Intercalators and Bcl-2 Inhibitors
por: Khoshneviszadeh, Mehdi, et al.
Publicado: (2021)

Modulation of neurotrophic signaling pathways by polyphenols
por: Moosavi, Fatemeh, et al.
Publicado: (2015)

Oxidative Aromatization, Cytotoxic Activity Evaluation and Conformational Study of Novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione Derivatives.
por: Motamedi, Radineh, et al.
Publicado: (2014)

Cinnamomum verum J. Presl. Bark essential oil: in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity
por: Saeedi, Mina, et al.
Publicado: (2022)

Correction: Cinnamomum verum J. Presl. Bark essential oil: in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity
por: Saeedi, Mina, et al.
Publicado: (2022)

Design, synthesis, cytotoxicity evaluation and docking studies of 1,2,4-triazine derivatives bearing different arylidene-hydrazinyl moieties as potential mTOR inhibitors
por: Ranjbar, Sara, et al.
Publicado: (2018)

Synthesis, biological evaluation and molecular docking analysis of vaniline–benzylidenehydrazine hybrids as potent tyrosinase inhibitors
por: Iraji, Aida, et al.
Publicado: (2020)

Novel 9-(alkylthio)-Acenaphtho[1,2-e]-1,2,4-triazine derivatives: synthesis, cytotoxic activity and molecular docking studies on B-cell lymphoma 2 (Bcl-2)
por: Mohammadi, Mohammad K, et al.
Publicado: (2014)

Benzylidene-6-hydroxy-3,4-dihydronaphthalenone chalconoids as potent tyrosinase inhibitors
por: Ranjbar, Sara, et al.
Publicado: (2021)

A Novel Imidazopyridine Derivative Exerts Anticancer Activity by Inducing Mitochondrial Pathway-Mediated Apoptosis
por: Wang, Juanli, et al.
Publicado: (2020)

Modulation of ERK1/2 and Akt Pathways Involved in the Neurotrophic Action of Caffeic Acid Alkyl Esters
por: Hosseini, Razieh, et al.
Publicado: (2018)

Barbiturate- and Thiobarbituarte-Based s-Triazine Hydrazone Derivatives with Promising Antiproliferative Activities
por: Al Rasheed, Hessa, et al.
Publicado: (2020)

Viral 3CL(pro) as a Target for Antiviral Intervention Using Milk-Derived Bioactive Peptides
por: Behzadipour, Yasaman, et al.
Publicado: (2021)

Substituted imidazopyridines as potent inhibitors of HCV replication()
por: Vliegen, Inge, et al.
Publicado: (2009)

Recent Developments in the Photochemical Synthesis of Functionalized Imidazopyridines
por: Tran, Christine, et al.
Publicado: (2022)

Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells
por: Firuzi, Omidreza, et al.
Publicado: (2019)

In Silico Screening of IL-1β Production Inhibitors Using Chemometric Tools
por: Sakhteman, Amirhossein, et al.
Publicado: (2017)

Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention
por: Cunha-Oliveira, Teresa, et al.
Publicado: (2020)

Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies
por: Elshaflu, Hana, et al.
Publicado: (2018)

Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolo-Pyrimidinones Tethered with Hydrazide-Hydrazones
por: Horchani, Mabrouk, et al.
Publicado: (2021)

Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells
por: Razzaghi-Asl, Nima, et al.
Publicado: (2016)

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels
por: O'Malley, Theresa, et al.
Publicado: (2018)

Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues
por: Papadakis, Georgios, et al.
Publicado: (2020)

Electrochemical Dehydrogenative C−H Aminomethylation of Imidazopyridines and Related Heterocycles
por: Huang, Raolin, et al.
Publicado: (2022)

Structure–Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis
por: Dichiara, Maria, et al.
Publicado: (2023)

Synthesis and Characterization of New Series of 1,3-5-Triazine Hydrazone Derivatives with Promising Antiproliferative Activity
por: Al Rasheed, Hessa H., et al.
Publicado: (2020)

Diterpenoids from Roots of Salvia lachnocalyx; In-silico and In-vitro Toxicity against Human Cancer Cell Lines
por: Hadavand Mirzaei, Hossein, et al.
Publicado: (2020)

Phytochemical Analysis and Biological Activity of Salvia compressa Vent.
por: Noorbakhsh, Firoozeh, et al.
Publicado: (2022)

Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1
por: Su, Jung-Chen, et al.
Publicado: (2018)

Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage
por: Reen, Gagandeep Kour, et al.
Publicado: (2019)

Iodine-Catalyzed Multicomponent Synthesis of Highly Fluorescent Pyrimidine-Linked Imidazopyridines
por: Acharya, Swadhin Swaraj, et al.
Publicado: (2022)

Regioselective C3–H Alkylation of Imidazopyridines with Donor–Acceptor Cyclopropanes
por: Dalkilic, Oguzhan, et al.
Publicado: (2023)

Discovery of Novel Imidazopyridine GSK-3β Inhibitors Supported by Computational Approaches
por: Buonfiglio, Rosa, et al.
Publicado: (2020)

Synthesis and Cytotoxicity Study of New Cyclopenta [b] quinoline-1,8-dione Derivatives
por: Miri, Ramin, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_g8f7hte4lkqan5he3de3jp3ggc