PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts, promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway

Cancer-associated fibroblasts (CAFs) plays an important role in the tumor microenvironment. The heterogeneity of CAFs affects the effect of CAFs on promoting or inhibiting tumors, which can be regulated by other cells in the tumor microenvironment through paracrine methods. The urokinase-type plasmi...

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Detalles Bibliográficos
Autores principales: Fang, Lingling, Che, Yun, Zhang, Chaoqi, Huang, Jianbing, Lei, Yuanyuan, Lu, Zhiliang, Sun, Nan, He, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878926/
https://www.ncbi.nlm.nih.gov/pubmed/33574243
http://dx.doi.org/10.1038/s41420-021-00410-6

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