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AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS

Oligodendrocyte dysfunction has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by progressive motor neuron loss. The failure of trophic support provided by oligodendrocytes is associated with a concomitant reduction in oligod...

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Detalles Bibliográficos
Autores principales:	Eykens, Caroline, Rossaert, Elisabeth, Duqué, Sandra, Rué, Laura, Bento-Abreu, André, Hersmus, Nicole, Lenaerts, Annette, Kerstens, Axelle, Corthout, Nikky, Munck, Sebastian, Van Damme, Philip, Holt, Matthew G., von Jonquires, Georg, Klugmann, Matthias, Van Den Bosch, Ludo, Robberecht, Wim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878966/ https://www.ncbi.nlm.nih.gov/pubmed/33614825 http://dx.doi.org/10.1016/j.omtm.2021.01.006

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