Next-Generation Sequencing of DDX41 in Myeloid Neoplasms Leads to Increased Detection of Germline Alterations

Previously considered rare, inherited hematologic malignancies are increasingly identified. Germline mutations in the RNA helicase DDX41 predispose to increased lifetime risks of myeloid neoplasms with disease often occurring later in life which presents challenges for germline recognition. To impro...

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Detalles Bibliográficos
Autores principales: Bannon, Sarah A., Routbort, Mark J., Montalban-Bravo, Guillermo, Mehta, Rohtesh S., Jelloul, Fatima Zahra, Takahashi, Koichi, Daver, Naval, Oran, Betul, Pemmaraju, Naveen, Borthakur, Gautam, Naqvi, Kiran, Issa, Ghayas, Sasaki, Koji, Alvarado, Yesid, Kadia, Tapan M., Konopleva, Marina, Shamanna, Rashmi Kanagal, Khoury, Joseph D., Ravandi, Farhad, Champlin, Richard, Kantarjian, Hagop M., Bhalla, Kapil, Garcia-Manero, Guillermo, Patel, Keyur P., DiNardo, Courtney D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878971/
https://www.ncbi.nlm.nih.gov/pubmed/33585199
http://dx.doi.org/10.3389/fonc.2020.582213

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