HDAC inhibition prevents transgene expression downregulation and loss-of-function in T-cell-receptor-transduced T cells

T cells that are gene-modified with tumor-specific T cell receptors are a promising treatment for metastatic melanoma patients. In a clinical trial, we treated seven metastatic melanoma patients with autologous T cells transduced to express a tyrosinase-reactive T cell receptor (TCR) (TIL 1383I) and...

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Detalles Bibliográficos
Autores principales: Moore, Tamson V., Scurti, Gina M., DeJong, Matthew, Wang, Siao-Yi, Dalheim, Annika V., Wagner, Courtney R., Hutchens, Kelli A., Speiser, Jodi J., Godellas, Constantine V., Fountain, Chris, Fleser, Jessica, Moudgil, Tarsem, Thomas, Mallory, Murray, David, Curti, Brendan D., Clark, Joseph I., Fox, Bernard A., Nishimura, Michael I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878989/
https://www.ncbi.nlm.nih.gov/pubmed/33614916
http://dx.doi.org/10.1016/j.omto.2021.01.014

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