Cargando…

Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma

BACKGROUND: Better treatments for glioblastoma (GBM) patients, in particular in the recurrent setting, are urgently needed. Clinical trials performed in Brazil indicated that intranasal delivery of perillyl alcohol (POH) might be effective in this patient group. NEO100, a highly purified version of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schönthal, Axel H, Peereboom, David M, Wagle, Naveed, Lai, Rose, Mathew, Anna J, Hurth, Kyle M, Simmon, Vincent F, Howard, Steven P, Taylor, Lynne P, Chow, Frances, da Fonseca, Clovis O, Chen, Thomas C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Clinical Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879254/ https://www.ncbi.nlm.nih.gov/pubmed/33604574 http://dx.doi.org/10.1093/noajnl/vdab005

Ejemplares similares

Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case
por: Schönthal, Axel H., et al.
Publicado: (2022)

Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development
por: Chen, Thomas C., et al.
Publicado: (2018)

Adjuvant effect of low-carbohydrate diet on outcomes of patients with recurrent glioblastoma under intranasal perillyl alcohol therapy
por: Santos, Juliana Guimaraes, et al.
Publicado: (2020)

The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers
por: Chen, Thomas C., et al.
Publicado: (2021)

Pharmacokinetic properties of the temozolomide perillyl alcohol conjugate (NEO212) in mice
por: Cho, Hee-Yeon, et al.
Publicado: (2020)

Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases
por: Chen, Thomas C., et al.
Publicado: (2016)

Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism
por: Faria, Giselle M., et al.
Publicado: (2020)

Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol
por: Fonseca, Clovis Orlando da, et al.
Publicado: (2008)

Cytotoxic impact of a perillyl alcohol–temozolomide conjugate, NEO212, on cutaneous T-cell lymphoma in vitro
por: Silva-Hirschberg, Catalina, et al.
Publicado: (2019)

Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram
por: Chen, Thomas C., et al.
Publicado: (2018)

NEO212, a Perillyl Alcohol-Temozolomide Conjugate, Triggers Macrophage Differentiation of Acute Myeloid Leukemia Cells and Blocks Their Tumorigenicity
por: Chen, Thomas C., et al.
Publicado: (2022)

Perillyl alcohol: Dynamic interactions with the lipid bilayer and implications for long-term inhalational chemotherapy for gliomas
por: da Fonseca, Clovis Orlando, et al.
Publicado: (2016)

Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia
por: Schönthal, Axel H., et al.
Publicado: (2021)

Intranasal Delivery of miR133b in a NEO100-Based Formulation Induces a Healing Response in Spinal Cord-Injured Mice
por: Danilov, Camelia A., et al.
Publicado: (2023)

Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats
por: Nehra, Geetika, et al.
Publicado: (2021)

Circulating Cell-Free DNA as a Prognostic and Molecular Marker for Patients with Brain Tumors under Perillyl Alcohol-Based Therapy
por: Faria, Giselle, et al.
Publicado: (2018)

Poly‐γ‐S‐perillyl‐l‐glutamate and Poly‐γ‐S‐perillyl‐d‐glutamate: Diastereomeric Alignment Media Used for the Investigation of the Alignment Process
por: Alcaraz Janßen, Marcel, et al.
Publicado: (2020)

Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles
por: Farazuddin, Mohammad, et al.
Publicado: (2012)

The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity
por: Nandurkar, Nitin S., et al.
Publicado: (2014)

Optimal Design of THEDES Based on Perillyl Alcohol and Ibuprofen
por: Silva, Eduardo, et al.
Publicado: (2020)

Synthesis and Antiproliferative Effects of Amino-Modified Perillyl Alcohol Derivatives
por: Hui, Zi, et al.
Publicado: (2014)

Effectiveness of recombinant Escherichia coli on the production of (R)-(+)-perillyl alcohol
por: Sun, Chao, et al.
Publicado: (2021)

Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans
por: Ansari, Moiz A., et al.
Publicado: (2016)

Perillyl alcohol has antibacterial effects and reduces ROS production in macrophages
por: FIGUEIREDO, Rebeca Dantas Alves, et al.
Publicado: (2020)

Perillyl Alcohol Inhibits Breast Cell Migration without Affecting Cell Adhesion
por: Wagner, Johanna E., et al.
Publicado: (2002)

Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol
por: Garcia, Diogo Gomes, et al.
Publicado: (2015)

Biosynthesis of (R)‐(+)‐perillyl alcohol by Escherichia coli expressing neryl pyrophosphate synthase
por: Sun, Chao, et al.
Publicado: (2022)

Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics against Escherichia coli
por: Sousa, Mariana, et al.
Publicado: (2023)

Enhancing Oral Bioavailability and Brain Biodistribution of Perillyl Alcohol Using Nanostructured Lipid Carriers
por: Peczek, Samila Horst, et al.
Publicado: (2023)

NEO412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo
por: Swenson, Steve, et al.
Publicado: (2018)

In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol
por: Andrade, Luciana Nalone, et al.
Publicado: (2016)

Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats
por: Cardoso-Teixeira, Ana Carolina, et al.
Publicado: (2018)

Selective Catalytic Isomerization of β‐Pinene Oxide to Perillyl Alcohol Enhanced by Protic Tetraimidazolium Nitrate
por: Li, Hui, et al.
Publicado: (2021)

Incorporation of Perillyl Alcohol into Lipid-Based Nanocarriers Enhances the Antiproliferative Activity in Malignant Glioma Cells
por: Ahmed, Tarek A., et al.
Publicado: (2023)

Targeting glioblastoma via intranasal administration of Ff bacteriophages
por: Dor-On, Eyal, et al.
Publicado: (2015)

Intranasal Delivery of Liposomes to Glioblastoma by Photostimulation of the Lymphatic System
por: Semyachkina-Glushkovskaya, Oxana, et al.
Publicado: (2022)

Update and developments in the treatment of glioblastoma multiforme – focus on bevacizumab
por: Wagle, Naveed, et al.
Publicado: (2010)

Perillyl alcohol modulates activation, permeability and integrity of human brain endothelial cells induced by Plasmodium falciparum
por: Marin, Adriana A, et al.
Publicado: (2023)

Development of Lomustine and n-Propyl Gallate Co-Encapsulated Liposomes for Targeting Glioblastoma Multiforme via Intranasal Administration
por: Katona, Gábor, et al.
Publicado: (2022)

NEO E-vita—NEO era!
por: Jakob, Heinz, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_70vqru2hvahiv9me4g3k2c4h9g