Cargando…
Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female
We report the case of an otherwise healthy 17-year-old female who presented for surgical removal of an enlarging “atypical cyst” on her scalp. During subtotal excision, only friable serosanguinous translucent ribbons of tissue were found. A histopathologic diagnosis of Langerhans cell histiocytosis...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879306/ https://www.ncbi.nlm.nih.gov/pubmed/33613231 http://dx.doi.org/10.1159/000511488 |
_version_ | 1783650501231902720 |
---|---|
author | Foster, Kent Wade Robinson, Shamika Kayo Tung-Hahn, Eleanor Gibbons, George Cruse, Carl Wayne Mudaliar, Kumaran Tung, Rebecca Kim, Wendy |
author_facet | Foster, Kent Wade Robinson, Shamika Kayo Tung-Hahn, Eleanor Gibbons, George Cruse, Carl Wayne Mudaliar, Kumaran Tung, Rebecca Kim, Wendy |
author_sort | Foster, Kent Wade |
collection | PubMed |
description | We report the case of an otherwise healthy 17-year-old female who presented for surgical removal of an enlarging “atypical cyst” on her scalp. During subtotal excision, only friable serosanguinous translucent ribbons of tissue were found. A histopathologic diagnosis of Langerhans cell histiocytosis (LCH) was rendered and imaging studies revealed extradural invasion of the tumor. Within weeks, the patient also developed progressive lymphadenopathy with grossly elevated levels of Epstein-Barr virus viral capsid antigen antibody levels. This report aims to highlight a unique presentation of LCH with discussion of workup, management, and avoidance of potential surgical complications. |
format | Online Article Text |
id | pubmed-7879306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-78793062021-02-18 Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female Foster, Kent Wade Robinson, Shamika Kayo Tung-Hahn, Eleanor Gibbons, George Cruse, Carl Wayne Mudaliar, Kumaran Tung, Rebecca Kim, Wendy Case Rep Dermatol Single Case We report the case of an otherwise healthy 17-year-old female who presented for surgical removal of an enlarging “atypical cyst” on her scalp. During subtotal excision, only friable serosanguinous translucent ribbons of tissue were found. A histopathologic diagnosis of Langerhans cell histiocytosis (LCH) was rendered and imaging studies revealed extradural invasion of the tumor. Within weeks, the patient also developed progressive lymphadenopathy with grossly elevated levels of Epstein-Barr virus viral capsid antigen antibody levels. This report aims to highlight a unique presentation of LCH with discussion of workup, management, and avoidance of potential surgical complications. S. Karger AG 2021-01-25 /pmc/articles/PMC7879306/ /pubmed/33613231 http://dx.doi.org/10.1159/000511488 Text en Copyright © 2021 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Single Case Foster, Kent Wade Robinson, Shamika Kayo Tung-Hahn, Eleanor Gibbons, George Cruse, Carl Wayne Mudaliar, Kumaran Tung, Rebecca Kim, Wendy Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female |
title | Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female |
title_full | Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female |
title_fullStr | Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female |
title_full_unstemmed | Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female |
title_short | Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female |
title_sort | multifocal langerhans cell histiocytosis: a unique presentation of eosinophilic granuloma with intracranial extension, massive lymphadenopathy, and epstein-barr viral infection in an adolescent female |
topic | Single Case |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879306/ https://www.ncbi.nlm.nih.gov/pubmed/33613231 http://dx.doi.org/10.1159/000511488 |
work_keys_str_mv | AT fosterkentwade multifocallangerhanscellhistiocytosisauniquepresentationofeosinophilicgranulomawithintracranialextensionmassivelymphadenopathyandepsteinbarrviralinfectioninanadolescentfemale AT robinsonshamikakayo multifocallangerhanscellhistiocytosisauniquepresentationofeosinophilicgranulomawithintracranialextensionmassivelymphadenopathyandepsteinbarrviralinfectioninanadolescentfemale AT tunghahneleanor multifocallangerhanscellhistiocytosisauniquepresentationofeosinophilicgranulomawithintracranialextensionmassivelymphadenopathyandepsteinbarrviralinfectioninanadolescentfemale AT gibbonsgeorge multifocallangerhanscellhistiocytosisauniquepresentationofeosinophilicgranulomawithintracranialextensionmassivelymphadenopathyandepsteinbarrviralinfectioninanadolescentfemale AT crusecarlwayne multifocallangerhanscellhistiocytosisauniquepresentationofeosinophilicgranulomawithintracranialextensionmassivelymphadenopathyandepsteinbarrviralinfectioninanadolescentfemale AT mudaliarkumaran multifocallangerhanscellhistiocytosisauniquepresentationofeosinophilicgranulomawithintracranialextensionmassivelymphadenopathyandepsteinbarrviralinfectioninanadolescentfemale AT tungrebecca multifocallangerhanscellhistiocytosisauniquepresentationofeosinophilicgranulomawithintracranialextensionmassivelymphadenopathyandepsteinbarrviralinfectioninanadolescentfemale AT kimwendy multifocallangerhanscellhistiocytosisauniquepresentationofeosinophilicgranulomawithintracranialextensionmassivelymphadenopathyandepsteinbarrviralinfectioninanadolescentfemale |