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Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female

We report the case of an otherwise healthy 17-year-old female who presented for surgical removal of an enlarging “atypical cyst” on her scalp. During subtotal excision, only friable serosanguinous translucent ribbons of tissue were found. A histopathologic diagnosis of Langerhans cell histiocytosis...

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Autores principales: Foster, Kent Wade, Robinson, Shamika Kayo, Tung-Hahn, Eleanor, Gibbons, George, Cruse, Carl Wayne, Mudaliar, Kumaran, Tung, Rebecca, Kim, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879306/
https://www.ncbi.nlm.nih.gov/pubmed/33613231
http://dx.doi.org/10.1159/000511488
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author Foster, Kent Wade
Robinson, Shamika Kayo
Tung-Hahn, Eleanor
Gibbons, George
Cruse, Carl Wayne
Mudaliar, Kumaran
Tung, Rebecca
Kim, Wendy
author_facet Foster, Kent Wade
Robinson, Shamika Kayo
Tung-Hahn, Eleanor
Gibbons, George
Cruse, Carl Wayne
Mudaliar, Kumaran
Tung, Rebecca
Kim, Wendy
author_sort Foster, Kent Wade
collection PubMed
description We report the case of an otherwise healthy 17-year-old female who presented for surgical removal of an enlarging “atypical cyst” on her scalp. During subtotal excision, only friable serosanguinous translucent ribbons of tissue were found. A histopathologic diagnosis of Langerhans cell histiocytosis (LCH) was rendered and imaging studies revealed extradural invasion of the tumor. Within weeks, the patient also developed progressive lymphadenopathy with grossly elevated levels of Epstein-Barr virus viral capsid antigen antibody levels. This report aims to highlight a unique presentation of LCH with discussion of workup, management, and avoidance of potential surgical complications.
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spelling pubmed-78793062021-02-18 Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female Foster, Kent Wade Robinson, Shamika Kayo Tung-Hahn, Eleanor Gibbons, George Cruse, Carl Wayne Mudaliar, Kumaran Tung, Rebecca Kim, Wendy Case Rep Dermatol Single Case We report the case of an otherwise healthy 17-year-old female who presented for surgical removal of an enlarging “atypical cyst” on her scalp. During subtotal excision, only friable serosanguinous translucent ribbons of tissue were found. A histopathologic diagnosis of Langerhans cell histiocytosis (LCH) was rendered and imaging studies revealed extradural invasion of the tumor. Within weeks, the patient also developed progressive lymphadenopathy with grossly elevated levels of Epstein-Barr virus viral capsid antigen antibody levels. This report aims to highlight a unique presentation of LCH with discussion of workup, management, and avoidance of potential surgical complications. S. Karger AG 2021-01-25 /pmc/articles/PMC7879306/ /pubmed/33613231 http://dx.doi.org/10.1159/000511488 Text en Copyright © 2021 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Foster, Kent Wade
Robinson, Shamika Kayo
Tung-Hahn, Eleanor
Gibbons, George
Cruse, Carl Wayne
Mudaliar, Kumaran
Tung, Rebecca
Kim, Wendy
Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female
title Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female
title_full Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female
title_fullStr Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female
title_full_unstemmed Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female
title_short Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female
title_sort multifocal langerhans cell histiocytosis: a unique presentation of eosinophilic granuloma with intracranial extension, massive lymphadenopathy, and epstein-barr viral infection in an adolescent female
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879306/
https://www.ncbi.nlm.nih.gov/pubmed/33613231
http://dx.doi.org/10.1159/000511488
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