A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile

We report a case of pruritic urticarial papules and plaques of pregnancy (PUPPP) starting with target lesions on both forearms at the end of second pregnancy. The patient's target lesions became generalized itchy edematous eczema lesions especially on her abdomen extended by pregnancy, which im...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishikawa-Nishimura, Mai, Kondo, Makoto, Matsushima, Yoshiaki, Habe, Koji, Yamanaka, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879330/
https://www.ncbi.nlm.nih.gov/pubmed/33613229
http://dx.doi.org/10.1159/000511494
_version_ 1783650504312619008
author Ishikawa-Nishimura, Mai
Kondo, Makoto
Matsushima, Yoshiaki
Habe, Koji
Yamanaka, Keiichi
author_facet Ishikawa-Nishimura, Mai
Kondo, Makoto
Matsushima, Yoshiaki
Habe, Koji
Yamanaka, Keiichi
author_sort Ishikawa-Nishimura, Mai
collection PubMed
description We report a case of pruritic urticarial papules and plaques of pregnancy (PUPPP) starting with target lesions on both forearms at the end of second pregnancy. The patient's target lesions became generalized itchy edematous eczema lesions especially on her abdomen extended by pregnancy, which immediately disappeared postpartum. The mechanism PUPPP has not been elucidated so far; however, the typical target lesion was the initial phenotype in the current case. To approach the pathophysiology of PUPPP, we examined the cytokine profile in the patient's serum before and after delivery. The upregulated Th2 cytokine profile including IL-9 and IL-33, and the reaction against skin-resident bacteria and fungus might be involved in PUPPP.
format Online
Article
Text
id pubmed-7879330
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-78793302021-02-18 A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile Ishikawa-Nishimura, Mai Kondo, Makoto Matsushima, Yoshiaki Habe, Koji Yamanaka, Keiichi Case Rep Dermatol Single Case We report a case of pruritic urticarial papules and plaques of pregnancy (PUPPP) starting with target lesions on both forearms at the end of second pregnancy. The patient's target lesions became generalized itchy edematous eczema lesions especially on her abdomen extended by pregnancy, which immediately disappeared postpartum. The mechanism PUPPP has not been elucidated so far; however, the typical target lesion was the initial phenotype in the current case. To approach the pathophysiology of PUPPP, we examined the cytokine profile in the patient's serum before and after delivery. The upregulated Th2 cytokine profile including IL-9 and IL-33, and the reaction against skin-resident bacteria and fungus might be involved in PUPPP. S. Karger AG 2021-01-25 /pmc/articles/PMC7879330/ /pubmed/33613229 http://dx.doi.org/10.1159/000511494 Text en Copyright © 2021 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Ishikawa-Nishimura, Mai
Kondo, Makoto
Matsushima, Yoshiaki
Habe, Koji
Yamanaka, Keiichi
A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile
title A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile
title_full A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile
title_fullStr A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile
title_full_unstemmed A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile
title_short A Case of Pruritic Urticarial Papules and Plaques of Pregnancy: Pathophysiology and Serum Cytokine Profile
title_sort case of pruritic urticarial papules and plaques of pregnancy: pathophysiology and serum cytokine profile
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879330/
https://www.ncbi.nlm.nih.gov/pubmed/33613229
http://dx.doi.org/10.1159/000511494
work_keys_str_mv AT ishikawanishimuramai acaseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT kondomakoto acaseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT matsushimayoshiaki acaseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT habekoji acaseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT yamanakakeiichi acaseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT ishikawanishimuramai caseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT kondomakoto caseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT matsushimayoshiaki caseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT habekoji caseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile
AT yamanakakeiichi caseofpruriticurticarialpapulesandplaquesofpregnancypathophysiologyandserumcytokineprofile

Ejemplares similares