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Breast and prostate glands affected by environmental substances
Environmental endocrine disruptor chemicals are substances that can alter the homeostasis of the endocrine system in living organisms. They can be released from several products used in daily activities. Once in the organism, they can disrupt the endocrine function by mimicking or blocking naturally...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879422/ https://www.ncbi.nlm.nih.gov/pubmed/33649835 http://dx.doi.org/10.3892/or.2021.7971 |
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author | Bleak, Tammy C. Calaf, Gloria M. |
author_facet | Bleak, Tammy C. Calaf, Gloria M. |
author_sort | Bleak, Tammy C. |
collection | PubMed |
description | Environmental endocrine disruptor chemicals are substances that can alter the homeostasis of the endocrine system in living organisms. They can be released from several products used in daily activities. Once in the organism, they can disrupt the endocrine function by mimicking or blocking naturally occurring hormones due to their similar chemical structure. This endocrine disruption is the most important cause of the well-known hormone-associate types of cancer. Additionally, it is decisive to determine the susceptibility of each organ to these compounds. Therefore, the present review aimed to summarize the effect of different environmental substances such as bisphenol A, dichlorodiphenyltrichloroethane and polychlorinated biphenyls in both the mammary and the prostate tissues. These organs were chosen due to their association with the hormonal system and their common features in carcinogenic mechanisms. Outcomes derived from the present review may provide evidence that should be considered in future debates regarding the effects of endocrine disruptors on carcinogenesis. |
format | Online Article Text |
id | pubmed-7879422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-78794222021-02-24 Breast and prostate glands affected by environmental substances Bleak, Tammy C. Calaf, Gloria M. Oncol Rep Review Environmental endocrine disruptor chemicals are substances that can alter the homeostasis of the endocrine system in living organisms. They can be released from several products used in daily activities. Once in the organism, they can disrupt the endocrine function by mimicking or blocking naturally occurring hormones due to their similar chemical structure. This endocrine disruption is the most important cause of the well-known hormone-associate types of cancer. Additionally, it is decisive to determine the susceptibility of each organ to these compounds. Therefore, the present review aimed to summarize the effect of different environmental substances such as bisphenol A, dichlorodiphenyltrichloroethane and polychlorinated biphenyls in both the mammary and the prostate tissues. These organs were chosen due to their association with the hormonal system and their common features in carcinogenic mechanisms. Outcomes derived from the present review may provide evidence that should be considered in future debates regarding the effects of endocrine disruptors on carcinogenesis. D.A. Spandidos 2021-04 2021-02-05 /pmc/articles/PMC7879422/ /pubmed/33649835 http://dx.doi.org/10.3892/or.2021.7971 Text en Copyright: © Bleak et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Bleak, Tammy C. Calaf, Gloria M. Breast and prostate glands affected by environmental substances |
title | Breast and prostate glands affected by environmental substances |
title_full | Breast and prostate glands affected by environmental substances |
title_fullStr | Breast and prostate glands affected by environmental substances |
title_full_unstemmed | Breast and prostate glands affected by environmental substances |
title_short | Breast and prostate glands affected by environmental substances |
title_sort | breast and prostate glands affected by environmental substances |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879422/ https://www.ncbi.nlm.nih.gov/pubmed/33649835 http://dx.doi.org/10.3892/or.2021.7971 |
work_keys_str_mv | AT bleaktammyc breastandprostateglandsaffectedbyenvironmentalsubstances AT calafgloriam breastandprostateglandsaffectedbyenvironmentalsubstances |