Truly epigenetic: A centromere finds a “neo” home

Murillo-Pineda and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202007210) use CRISPR-Cas9–based genetic engineering in human cells to induce a new functional centromere at a naive chromosomal site. Long-read DNA sequencing at the neocentromere provides firm evidence that centromere e...

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Detalles Bibliográficos
Autores principales: Carty, Ben L., Dunleavy, Elaine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879491/
https://www.ncbi.nlm.nih.gov/pubmed/33566070
http://dx.doi.org/10.1083/jcb.202101027
Descripción
Sumario:Murillo-Pineda and colleagues (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202007210) use CRISPR-Cas9–based genetic engineering in human cells to induce a new functional centromere at a naive chromosomal site. Long-read DNA sequencing at the neocentromere provides firm evidence that centromere establishment is a truly epigenetic event.

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