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Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013

BACKGROUND: Bronchiolitis caused by respiratory syncytial virus (RSV) is a major cause of mortality and morbidity in infants. AIM: To describe RSV epidemiology in children in the community in a high-income setting. METHODS: We used stored blood samples from the United Kingdom Born in Bradford cohort...

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Autores principales: Zylbersztejn, Ania, Pembrey, Lucy, Goldstein, Harvey, Berbers, Guy, Schepp, Rutger, van der Klis, Fiona, Sande, Charles, Mason, Dan, Wright, John, Smyth, Rosalind, Hardelid, Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879500/
https://www.ncbi.nlm.nih.gov/pubmed/33573711
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.6.2000023
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author Zylbersztejn, Ania
Pembrey, Lucy
Goldstein, Harvey
Berbers, Guy
Schepp, Rutger
van der Klis, Fiona
Sande, Charles
Mason, Dan
Wright, John
Smyth, Rosalind
Hardelid, Pia
author_facet Zylbersztejn, Ania
Pembrey, Lucy
Goldstein, Harvey
Berbers, Guy
Schepp, Rutger
van der Klis, Fiona
Sande, Charles
Mason, Dan
Wright, John
Smyth, Rosalind
Hardelid, Pia
author_sort Zylbersztejn, Ania
collection PubMed
description BACKGROUND: Bronchiolitis caused by respiratory syncytial virus (RSV) is a major cause of mortality and morbidity in infants. AIM: To describe RSV epidemiology in children in the community in a high-income setting. METHODS: We used stored blood samples from the United Kingdom Born in Bradford cohort study that had been collected at birth, age 1 and 2 years old, tested for IgG RSV postfusion F antibody and linked to questionnaires and primary and hospital care records. We used finite mixture models to classify children as RSV infected/not infected according to their antibody concentrations at age 1 and 2 years. We assessed risk factors for primary RSV infection at each age using Poisson regression models. RESULTS: The study cohort included 700 children with cord blood samples; 490 had additional blood samples taken at both ages 1 and 2 years old. Of these 490 children, 258 (53%; 95% confidence interval (CI): 48–57%) were first infected with RSV at age 1, 99 of whom (38%; 95% CI: 33–43%) had been in contact with healthcare during peak RSV season (November–January). Having older siblings, birth in October–June and attending formal childcare were associated with risk of RSV infection in infancy. By age 2, a further 164 of 490 children (33%; 95% CI: 29–38%) had been infected. CONCLUSION: Over half of children experienced RSV infection in infancy, a further one third had evidence of primary RSV infection by age 2, and one in seven remained seronegative by their second birthday. These findings will inform future analyses to assess the cost-effectiveness of RSV vaccination programmes in high-income settings.
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spelling pubmed-78795002021-02-23 Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013 Zylbersztejn, Ania Pembrey, Lucy Goldstein, Harvey Berbers, Guy Schepp, Rutger van der Klis, Fiona Sande, Charles Mason, Dan Wright, John Smyth, Rosalind Hardelid, Pia Euro Surveill Research BACKGROUND: Bronchiolitis caused by respiratory syncytial virus (RSV) is a major cause of mortality and morbidity in infants. AIM: To describe RSV epidemiology in children in the community in a high-income setting. METHODS: We used stored blood samples from the United Kingdom Born in Bradford cohort study that had been collected at birth, age 1 and 2 years old, tested for IgG RSV postfusion F antibody and linked to questionnaires and primary and hospital care records. We used finite mixture models to classify children as RSV infected/not infected according to their antibody concentrations at age 1 and 2 years. We assessed risk factors for primary RSV infection at each age using Poisson regression models. RESULTS: The study cohort included 700 children with cord blood samples; 490 had additional blood samples taken at both ages 1 and 2 years old. Of these 490 children, 258 (53%; 95% confidence interval (CI): 48–57%) were first infected with RSV at age 1, 99 of whom (38%; 95% CI: 33–43%) had been in contact with healthcare during peak RSV season (November–January). Having older siblings, birth in October–June and attending formal childcare were associated with risk of RSV infection in infancy. By age 2, a further 164 of 490 children (33%; 95% CI: 29–38%) had been infected. CONCLUSION: Over half of children experienced RSV infection in infancy, a further one third had evidence of primary RSV infection by age 2, and one in seven remained seronegative by their second birthday. These findings will inform future analyses to assess the cost-effectiveness of RSV vaccination programmes in high-income settings. European Centre for Disease Prevention and Control (ECDC) 2021-02-11 /pmc/articles/PMC7879500/ /pubmed/33573711 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.6.2000023 Text en This article is copyright of the authors or their affiliated institutions, 2021. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research
Zylbersztejn, Ania
Pembrey, Lucy
Goldstein, Harvey
Berbers, Guy
Schepp, Rutger
van der Klis, Fiona
Sande, Charles
Mason, Dan
Wright, John
Smyth, Rosalind
Hardelid, Pia
Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013
title Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013
title_full Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013
title_fullStr Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013
title_full_unstemmed Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013
title_short Respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, Born in Bradford cohort, England, 2008 to 2013
title_sort respiratory syncytial virus in young children: community cohort study integrating serological surveys, questionnaire and electronic health records, born in bradford cohort, england, 2008 to 2013
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879500/
https://www.ncbi.nlm.nih.gov/pubmed/33573711
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.6.2000023
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