Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021

The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicit...

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Autores principales: Abu Jabal, Kamal, Ben-Amram, Hila, Beiruti, Karine, Batheesh, Yunis, Sussan, Christian, Zarka, Salman, Edelstein, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879501/
https://www.ncbi.nlm.nih.gov/pubmed/33573712
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.6.2100096
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author Abu Jabal, Kamal
Ben-Amram, Hila
Beiruti, Karine
Batheesh, Yunis
Sussan, Christian
Zarka, Salman
Edelstein, Michael
author_facet Abu Jabal, Kamal
Ben-Amram, Hila
Beiruti, Karine
Batheesh, Yunis
Sussan, Christian
Zarka, Salman
Edelstein, Michael
author_sort Abu Jabal, Kamal
collection PubMed
description The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.
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spelling pubmed-78795012021-02-23 Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021 Abu Jabal, Kamal Ben-Amram, Hila Beiruti, Karine Batheesh, Yunis Sussan, Christian Zarka, Salman Edelstein, Michael Euro Surveill Rapid Communication The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination. European Centre for Disease Prevention and Control (ECDC) 2021-02-11 /pmc/articles/PMC7879501/ /pubmed/33573712 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.6.2100096 Text en This article is copyright of the authors or their affiliated institutions, 2021. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Abu Jabal, Kamal
Ben-Amram, Hila
Beiruti, Karine
Batheesh, Yunis
Sussan, Christian
Zarka, Salman
Edelstein, Michael
Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021
title Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021
title_full Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021
title_fullStr Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021
title_full_unstemmed Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021
title_short Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021
title_sort impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the bnt162b2 mrna covid-19 vaccine: real-world evidence from healthcare workers, israel, december 2020 to january 2021
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879501/
https://www.ncbi.nlm.nih.gov/pubmed/33573712
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.6.2100096
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