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Use of a small DNA virus model to investigate mechanisms of CpG dinucleotide-induced attenuation of virus replication

Suppression of the CpG dinucleotide is widespread in RNA viruses infecting vertebrates and plants, and in the genomes of retroviruses and small mammalian DNA viruses. The functional basis for CpG suppression in the latter was investigated through the construction of mutants of the parvovirus, minute...

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Detalles Bibliográficos
Autores principales: Loew, Lisa, Goonawardane, Niluka, Ratcliff, Jeremy, Nguyen, Dung, Simmonds, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879557/
https://www.ncbi.nlm.nih.gov/pubmed/32783803
http://dx.doi.org/10.1099/jgv.0.001477