Cargando…

Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review

Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Xiaolong, Shen, Huafei, Zhu, Mingyu, Shi, Yuanfei, Wang, Huanping, Chen, Zhimei, Huang, Xin, Wang, Yungui, Jin, Jie, Xie, Wanzhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879616/
https://www.ncbi.nlm.nih.gov/pubmed/33573663
http://dx.doi.org/10.1186/s13039-021-00530-9
_version_ 1783650549513584640
author Zheng, Xiaolong
Shen, Huafei
Zhu, Mingyu
Shi, Yuanfei
Wang, Huanping
Chen, Zhimei
Huang, Xin
Wang, Yungui
Jin, Jie
Xie, Wanzhuo
author_facet Zheng, Xiaolong
Shen, Huafei
Zhu, Mingyu
Shi, Yuanfei
Wang, Huanping
Chen, Zhimei
Huang, Xin
Wang, Yungui
Jin, Jie
Xie, Wanzhuo
author_sort Zheng, Xiaolong
collection PubMed
description Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as t(9;22) (q34;q11) and KMT2A (MLL) rearrangement. These specific abnormalities usually have important guiding significance in MPAL diagnosis, targeted therapy and prognosis judgment. In this paper, we reported a case of MPAL, T/myeloid (M5) with an unfrequent combination of PML-RARα positivity and t(15;17). The treatment was successful with chemotherapy for both AML and ALL with daunorubicin, cytarabine (DA) and vincristine, prednisone (VP). We reported here this suggestive MPAL case of rare disease condition and effective treatment, in order to provide experience for the early diagnosis and treatment of similar patients.
format Online
Article
Text
id pubmed-7879616
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-78796162021-02-17 Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review Zheng, Xiaolong Shen, Huafei Zhu, Mingyu Shi, Yuanfei Wang, Huanping Chen, Zhimei Huang, Xin Wang, Yungui Jin, Jie Xie, Wanzhuo Mol Cytogenet Case Report Mixed phenotype acute leukemia (MPAL) is an uncommon type of leukemia. It is one kind of malignant clonal diseases that expresses more than one genealogical specific antigen simultaneously. Most MPAL patients are associated with clonal chromosomal abnormalities and molecular genetic changes, such as t(9;22) (q34;q11) and KMT2A (MLL) rearrangement. These specific abnormalities usually have important guiding significance in MPAL diagnosis, targeted therapy and prognosis judgment. In this paper, we reported a case of MPAL, T/myeloid (M5) with an unfrequent combination of PML-RARα positivity and t(15;17). The treatment was successful with chemotherapy for both AML and ALL with daunorubicin, cytarabine (DA) and vincristine, prednisone (VP). We reported here this suggestive MPAL case of rare disease condition and effective treatment, in order to provide experience for the early diagnosis and treatment of similar patients. BioMed Central 2021-02-11 /pmc/articles/PMC7879616/ /pubmed/33573663 http://dx.doi.org/10.1186/s13039-021-00530-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Zheng, Xiaolong
Shen, Huafei
Zhu, Mingyu
Shi, Yuanfei
Wang, Huanping
Chen, Zhimei
Huang, Xin
Wang, Yungui
Jin, Jie
Xie, Wanzhuo
Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review
title Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review
title_full Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review
title_fullStr Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review
title_full_unstemmed Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review
title_short Mixed phenotype acute leukemia with PML-RARα positive: a case report and literature review
title_sort mixed phenotype acute leukemia with pml-rarα positive: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879616/
https://www.ncbi.nlm.nih.gov/pubmed/33573663
http://dx.doi.org/10.1186/s13039-021-00530-9
work_keys_str_mv AT zhengxiaolong mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT shenhuafei mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT zhumingyu mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT shiyuanfei mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT wanghuanping mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT chenzhimei mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT huangxin mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT wangyungui mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT jinjie mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview
AT xiewanzhuo mixedphenotypeacuteleukemiawithpmlrarapositiveacasereportandliteraturereview