Cargando…

A randomized placebo-controlled phase I clinical trial to evaluate the immunomodulatory activities of Atractylodes lancea (Thunb) DC. in healthy Thai subjects

BACKGROUND: Atractylodes lancea (Thunb) DC. (AL) and bioactive compounds β-eudesmol and atractylodin have been demonstrated in the in vitro and in vivo studies for their potential clinical use in cholangiocarcinoma. The study was a randomized, double-blinded, placebo-controlled phase I clinical tria...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kulma, Inthuon, Panrit, Luxsana, Plengsuriyakarn, Tullayakorn, Chaijaroenkul, Wanna, Warathumpitak, Siriprapa, Na-Bangchang, Kesara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879636/ https://www.ncbi.nlm.nih.gov/pubmed/33579265 http://dx.doi.org/10.1186/s12906-020-03199-6

Ejemplares similares

Research and Development of Atractylodes lancea (Thunb) DC. as a Promising Candidate for Cholangiocarcinoma Chemotherapeutics
por: Na-Bangchang, Kesara, et al.
Publicado: (2017)

Suppression of Cholangiocarcinoma Cell Growth and Proliferation by Atractylodes lancea (Thunb) DC. through ERK-Signaling Cascade
por: Martviset, Pongsakorn, et al.
Publicado: (2021)

Preclinical studies of toxicity and anti-cholangiocarcinoma activity of the standardized capsule formulation of Atractylodes lancea (Thunb.) DC
por: Plengsuriyakarn, Tullayakorn, et al.
Publicado: (2023)

Apoptotic and Anti-metastatic Effects of Atractylodes lancea (Thunb.) DC. in a Hamster Model of Cholangiocarcinoma
por: Sonsomnuek, Paradon, et al.
Publicado: (2022)

Atractylodin and β-eudesmol from Atractylodes lancea (Thunb.) DC. Inhibit Cholangiocarcinoma Cell Proliferation by Downregulating the Notch Signaling Pathway
por: Vanaroj, Peeranate, et al.
Publicado: (2023)

Bioactive constituents isolated from Atractylodes lancea (Thunb.) DC. rhizome exhibit synergistic effect against cholangiocarcinoma cell
por: Martviset, Pongsakorn, et al.
Publicado: (2018)

Bioassay for total serum bioactivity of Atractylodes lancea
por: Na-Bangchang, Kesara, et al.
Publicado: (2023)

Phase I clinical trial to evaluate the safety and pharmacokinetics of capsule formulation of the standardized extract of Atractylodes lancea
por: Na-Bangchang, Kesara, et al.
Publicado: (2021)

Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice
por: Muhamad, Nadda, et al.
Publicado: (2022)

Cytotoxicity, Cell Cycle Arrest, and Apoptosis Induction Activity of Ethyl-p-methoxycinnamate in Cholangiocarcinoma Cell
por: Muhamad, Phunuch, et al.
Publicado: (2020)

Pharmacological effects of medicinal components of Atractylodes lancea (Thunb.) DC.
por: Jun, Xie, et al.
Publicado: (2018)

The influences of inorganic elements in soil on the development of famous - region Atractylodes lancea (Thunb.) DC
por: Zhang, Weiwanqi, et al.
Publicado: (2015)

Network Pharmacology and Experimental Validation to Investigate the Antidepressant Potential of Atractylodes lancea (Thunb.) DC.
por: Nguyen, Ly Thi Huong, et al.
Publicado: (2022)

Diverse Intercropping Patterns Enhance the Productivity and Volatile Oil Yield of Atractylodes lancea (Thunb.) DC.
por: Peng, Zheng, et al.
Publicado: (2021)

Antimalarial activity of plumbagin in vitro and in animal models
por: Sumsakul, Wiriyaporn, et al.
Publicado: (2014)

Geoherbalism Metabolomic Analysis of Atractylodes lancea (Thunb.) DC. by LC-Triple TOF-MS/MS and GC-MS
por: Qiu, Hailong, et al.
Publicado: (2023)

Early stem growth mutation alters metabolic flux changes enhance sesquiterpenoids biosynthesis in Atractylodes lancea (Thunb.) DC.
por: Wang, Di, et al.
Publicado: (2022)

Genetic Diversity of Human Host Genes Involved in Immune Response and the Binding of Malaria Parasite in Patients Residing along the Thai-Myanmar border
por: Sirisabhabhorn, Kridsada, et al.
Publicado: (2021)

Genetic Diversity of Plasmodium vivax Field Isolates from the Thai–Myanmar Border during the Period of 2006–2016
por: Jalei, Abdifatah Abdullahi, et al.
Publicado: (2023)

In vitro antimalarial drug susceptibility in Thai border areas from 1998–2003
por: Chaijaroenkul, Wanna, et al.
Publicado: (2005)

Anticancer activities against cholangiocarcinoma, toxicity and pharmacological activities of Thai medicinal plants in animal models
por: Plengsuriyakarn, Tullayakorn, et al.
Publicado: (2012)

Pharmacokinetics, toxicity, and cytochrome P450 modulatory activity of plumbagin
por: Sumsakul, Wiriyaporn, et al.
Publicado: (2016)

Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
por: Muhamad, Nadda, et al.
Publicado: (2018)

Anticholangiocarcinoma activity and toxicity of the Kaempferia galanga Linn. Rhizome ethanolic extract
por: Amuamuta, Asmare, et al.
Publicado: (2017)

Modulatory Effects of Atractylodin and β-Eudesmol on Human Cytochrome P450 Enzymes: Potential Drug-Drug Interactions
por: Thiengsusuk, Artitaya, et al.
Publicado: (2023)

Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro
por: Mahavorasirikul, Wiratchanee, et al.
Publicado: (2010)

Four years’ monitoring of in vitro sensitivity and candidate molecular markers of resistance of Plasmodium falciparum to artesunate-mefloquine combination in the Thai-Myanmar border
por: Phompradit, Papichaya, et al.
Publicado: (2014)

Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar border
por: Na-Bangchang, Kesara, et al.
Publicado: (2010)

The Potential of Atractylodin-Loaded PLGA Nanoparticles as Chemotherapeutic for Cholangiocarcinoma
por: Muhamad, Nadda, et al.
Publicado: (2020)

Potential of Alpha-Mangostin-Loaded PLGA Nanoparticles for Cholangiocarcinoma Treatment
por: Tahir, Asma, et al.
Publicado: (2022)

Effects of β-eudesmol and atractylodin on target genes and hormone related to cardiotoxicity, hepatotoxicity, and endocrine disruption in developing zebrafish embryos
por: Tshering, Gyem, et al.
Publicado: (2022)

Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border: integration of clinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity
por: Na-Bangchang, Kesara, et al.
Publicado: (2013)

Two Novel Sesquiterpenoid Glycosides from the Rhizomes of Atractylodes lancea
por: Liu, Lanying, et al.
Publicado: (2022)

Notch signaling in the pathogenesis, progression and identification of potential targets for cholangiocarcinoma (Review)
por: Vanaroj, Peeranate, et al.
Publicado: (2022)

β-Eudesmol Inhibits the Migration of Cholangiocarcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via PI3K/AKT and p38MAPK Modulation
por: Acharya, Bishwanath, et al.
Publicado: (2022)

Molecular Targets and Signaling Pathways in Cholangiocarcinoma: A Systematic Review
por: Idris, Rehab, et al.
Publicado: (2023)

Prevalence and distribution of glucose-6-phosphate dehydrogenase (G6PD) variants in Thai and Burmese populations in malaria endemic areas of Thailand
por: Phompradit, Papichaya, et al.
Publicado: (2011)

Genome survey sequencing of Atractylodes lancea and identification of its SSR markers
por: Shan, Tingyu, et al.
Publicado: (2020)

Evaluation of Rapid Diagnostics for Plasmodium falciparum and P. vivax in Mae Sot Malaria Endemic Area, Thailand
por: Chaijaroenkul, Wanna, et al.
Publicado: (2011)

Nested-PCR and a New ELISA-Based NovaLisa Test Kit for Malaria Diagnosis in an Endemic Area of Thailand
por: Thongdee, Pimwan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3o1gs5177ode5pkcqnhpi0im69