The Effect of SF3B1 Mutation on the DNA Damage Response and Nonsense-Mediated mRNA Decay in Cancer

Recurrent mutations in splicing factor 3B subunit 1 (SF3B1) have been identified in several malignancies and are associated with an increased expression of 3’ cryptic transcripts as a result of alternative branchpoint recognition. A large fraction of cryptic transcripts associated with SF3B1 mutatio...

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Detalles Bibliográficos
Autores principales: Leeksma, Alexander C., Derks, Ingrid A. M., Kasem, M. Haidar, Kilic, Emine, de Klein, Annelies, Jager, Martine J., van de Loosdrecht, Arjan A., Jansen, Joop H., Navrkalova, Veronika, Faber, Laura M., Zaborsky, Nadja, Egle, Alexander, Zenz, Thorsten, Pospisilova, Sarka, Abdel-Wahab, Omar, Kater, Arnon P., Eldering, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880055/
https://www.ncbi.nlm.nih.gov/pubmed/33585229
http://dx.doi.org/10.3389/fonc.2020.609409

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