Cargando…

Safety and feasibility of using acellular sterile filtered amniotic fluid as a treatment for patients with COVID-19: protocol for a randomised, double-blinded, placebo-controlled clinical trial

INTRODUCTION: Human amniotic fluid (hAF) has been shown to reduce inflammation in multiple experimental models. hAF has previously been approved by the US Food and Drug Administration (FDA) as a human cellular and tissue product for tissue injury for human administration, and used safely in thousand...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tonna, Joseph E, Pierce, Jan, Hatton, Nathan, Lewis, Giavonni, Phillips, John D, Messina, Alyssa, Skidmore, Chloe R, Taylor, Kirsten, Selzman, Craig H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Intensive Care
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880092/ https://www.ncbi.nlm.nih.gov/pubmed/33574155 http://dx.doi.org/10.1136/bmjopen-2020-045162

Ejemplares similares

A pilot trial of human amniotic fluid for the treatment of COVID-19
por: Selzman, Craig H., et al.
Publicado: (2021)

Inhaled amikacin versus placebo to prevent ventilator-associated pneumonia: the AMIKINHAL double-blind multicentre randomised controlled trial protocol
por: Tavernier, Elsa, et al.
Publicado: (2021)

Dexmedetomidine after Cardiac Surgery for Prevention of Delirium (EXACTUM) trial protocol: a multicentre randomised, double-blind, placebo-controlled trial
por: Gargadennec, Thomas, et al.
Publicado: (2022)

ImmunoSep (Personalised Immunotherapy in Sepsis) international double-blind, double-dummy, placebo-controlled randomised clinical trial: study protocol
por: Kotsaki, Antigone, et al.
Publicado: (2022)

Adjuvant Lipoic acid Injection in Sepsis treatment in China (ALIS study): protocol for a randomised, single-blind, placebo-controlled trial
por: Hu, Linhui, et al.
Publicado: (2023)

Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial
por: Shelton, Kenneth T, et al.
Publicado: (2018)

Study protocol for a prospective randomised double-blind placebo-controlled clinical trial investigating a Better Outcome with Melatonin compared to Placebo Administered to normalize sleep–wake cycle and treat hypoactive ICU Delirium: the Basel BOMP-AID study
por: Hollinger, Alexa, et al.
Publicado: (2020)

Ciclosporin to Protect Renal function In Cardiac Surgery (CiPRICS): a study protocol for a double-blind, randomised, placebo-controlled, proof-of-concept study
por: Ederoth, Per, et al.
Publicado: (2016)

Ascorbic Acid, Corticosteroids and Thiamine in Sepsis (ACTS) protocol and statistical analysis plan: a prospective, multicentre, double-blind, randomised, placebo-controlled clinical trial
por: Moskowitz, Ari, et al.
Publicado: (2019)

Effect of intravenous GLutamine supplementation IN Trauma patients receiving enteral nutrition study protocol (GLINT Study): a prospective, blinded, randomised, placebo-controlled clinical trial
por: Al Balushi, Ruqaiya M, et al.
Publicado: (2011)

Prevention of early ventilation-acquired pneumonia (VAP) in comatose brain-injured patients by a single dose of ceftriaxone: PROPHY-VAP study protocol, a multicentre, randomised, double-blind, placebo-controlled trial
por: Dahyot-Fizelier, Claire, et al.
Publicado: (2018)

Efficacy of halopeRIdol to decrease the burden of Delirium In adult Critically ill patiEnts (EuRIDICE): study protocol for a prospective randomised multi-centre double-blind placebo-controlled clinical trial in the Netherlands
por: Smit, Lisa, et al.
Publicado: (2020)

A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2)
por: Geven, Christopher, et al.
Publicado: (2019)

Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study)
por: Amrein, Karin, et al.
Publicado: (2019)

Feasibility of melatonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study
por: Burry, Lisa, et al.
Publicado: (2017)

Dexmedetomidine and sleep quality in mechanically ventilated critically ill patients: study protocol for a randomised placebo-controlled trial
por: Oxlund, Jakob, et al.
Publicado: (2022)

Detailed assessment of benefits and risks of retrievable inferior vena cava filters on patients with complicated injuries: the da Vinci multicentre randomised controlled trial study protocol
por: Ho, Kwok M, et al.
Publicado: (2017)

Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT
por: Johnstone, Jennie, et al.
Publicado: (2019)

The effect of blinding on estimates of mortality in randomised clinical trials of intensive care interventions: protocol for a systematic review and meta-analysis
por: Anthon, Carl Thomas, et al.
Publicado: (2017)

Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis (RECORDS): study protocol for a multicentre, placebo-controlled, biomarker-guided, adaptive Bayesian design basket trial
por: Fleuriet, Jérôme, et al.
Publicado: (2023)

Barriers and facilitators to resuming meaningful daily activities among critical illness survivors in the UK: a qualitative content analysis
por: Scheunemann, Leslie, et al.
Publicado: (2022)

Study protocol for the safety and efficacy of probiotic therapy on days alive and out of hospital in adult ICU patients: the multicentre, randomised, placebo-controlled Restoration Of gut microflora in Critical Illness Trial (ROCIT)
por: Litton, Edward, et al.
Publicado: (2020)

Improving gender equity in critical care medicine: a protocol to establish priorities and strategies for implementation
por: Parsons Leigh, Jeanna, et al.
Publicado: (2020)

COBI (COntinuous hyperosmolar therapy for traumatic Brain-Injured patients) trial protocol: a multicentre randomised open-label trial with blinded adjudication of primary outcome
por: Roquilly, Antoine, et al.
Publicado: (2017)

Effects of intravenous sivelestat sodium on prevention of acute respiratory distress syndrome in patients with sepsis: study protocol for a double-blind multicentre randomised controlled trial
por: Ma, Shaolei, et al.
Publicado: (2023)

Efficacy and safety of 1C class antiarrhythmic agent (propafenone) for supraventricular arrhythmias in septic shock compared to amiodarone: protocol of a prospective randomised double-blind study
por: Balik, Martin, et al.
Publicado: (2019)

IMPOSE (IMProving Outcomes after Sepsis)—the effect of a multidisciplinary follow-up service on health-related quality of life in patients postsepsis syndromes—a double-blinded randomised controlled trial: protocol
por: Paratz, Jennifer D, et al.
Publicado: (2014)

Efficacy and safety of exogenous surfactant therapy in patients under 12 months of age invasively ventilated for severe bronchiolitis (SURFABRON): protocol for a multicentre, randomised, double-blind, controlled, non-profit trial
por: Biban, Paolo, et al.
Publicado: (2020)

Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3): a multicentre, randomised, blinded-endpoint, comparative effectiveness study of brain tissue oxygen and intracranial pressure monitoring versus intracranial pressure alone
por: Bernard, Francis, et al.
Publicado: (2022)

Intensive Care Weaning (iCareWean) protocol on weaning from mechanical ventilation: a single-blinded multicentre randomised control trial comparing an open-loop decision support system and routine care, in the general intensive care unit
por: Vizcaychipi, M P, et al.
Publicado: (2020)

Mapping structure, process and outcomes in the removal of low-value care practices in Canadian intensive care units: protocol for a mixed-methods exploratory study
por: Parsons Leigh, Jeanna, et al.
Publicado: (2019)

Review of novel therapeutics in cardiac arrest (ReNTICA): systematic review protocol
por: Murphy, Travis W, et al.
Publicado: (2022)

Sedation strategy and ICU delirium: a multicentre, population-based propensity score-matched cohort study
por: Casault, Colin, et al.
Publicado: (2021)

Family coaching during Spontaneous Awakening Trials and Spontaneous Breathing Trials (FamCAB): pilot study protocol
por: Shahid, Anmol, et al.
Publicado: (2023)

Protocol describing a systematic review and mixed methods consensus process to define the deteriorated ward patient
por: Malycha, James, et al.
Publicado: (2022)

Methods for determination of optimal positive end-expiratory pressure: a protocol for a scoping review
por: Edginton, Stefan, et al.
Publicado: (2023)

Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis
por: Kamaleldin, Mostafa, et al.
Publicado: (2022)

Sacrifice and solidarity: a qualitative study of family experiences of death and bereavement in critical care settings during the pandemic
por: Dennis, Brittany, et al.
Publicado: (2022)

Amniotic fluid embolism
por: Thongrong, Cattleya, et al.
Publicado: (2013)

What counts as patient-important upper gastrointestinal bleeding in the ICU? A mixed-methods study protocol of patient and family perspectives
por: Cook, Deborah J, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ils8q6vsldffnvmumr6p7k3ijg