Hollow-fiber bioreactor production of extracellular vesicles from human bone marrow mesenchymal stromal cells yields nanovesicles that mirrors the immuno-modulatory antigenic signature of the producer cell

BACKGROUND: Extracellular vesicles (EVs) produced by human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical effectiveness towards immune-mediated diseases. The large amounts of stem cell-derived EVs required for clinical testing suggest that bior...

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Detalles Bibliográficos
Autores principales: Gobin, Jonathan, Muradia, Gauri, Mehic, Jelica, Westwood, Carole, Couvrette, Lauren, Stalker, Andrew, Bigelow, Stewart, Luebbert, Christian C., Bissonnette, Frédéric St-Denis, Johnston, Michael J. W., Sauvé, Simon, Tam, Roger Y., Wang, Lisheng, Rosu-Myles, Michael, Lavoie, Jessie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880218/
https://www.ncbi.nlm.nih.gov/pubmed/33579358
http://dx.doi.org/10.1186/s13287-021-02190-3

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