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Fractional methicillin-resistant Staphylococcus aureus infection model under Caputo operator

This study provides a detailed exposition of in-hospital community-acquired methicillin-resistant S. aureus (CA-MRSA) which is a new strain of MRSA, and hospital-acquired methicillin-resistant S. aureus (HA-MRSA) employing Caputo fractional operator. These two strains of MRSA, referred to as staph,...

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Autores principales: Acay, Bahar, Inc, Mustafa, Khan, Amir, Yusuf, Abdullahi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880223/
https://www.ncbi.nlm.nih.gov/pubmed/33613142
http://dx.doi.org/10.1007/s12190-021-01502-3
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author Acay, Bahar
Inc, Mustafa
Khan, Amir
Yusuf, Abdullahi
author_facet Acay, Bahar
Inc, Mustafa
Khan, Amir
Yusuf, Abdullahi
author_sort Acay, Bahar
collection PubMed
description This study provides a detailed exposition of in-hospital community-acquired methicillin-resistant S. aureus (CA-MRSA) which is a new strain of MRSA, and hospital-acquired methicillin-resistant S. aureus (HA-MRSA) employing Caputo fractional operator. These two strains of MRSA, referred to as staph, have been a serious problem in hospitals and it is known that they give rise to more deaths per year than AIDS. Hence, the transmission dynamics determining whether the CA-MRSA overtakes HA-MRSA is analyzed by means of a non-local fractional derivative. We show the existence and uniqueness of the solutions of the fractional staph infection model through fixed-point theorems. Moreover, stability analysis and iterative solutions are furnished by the recursive procedure. We make use of the parameter values obtained from the Beth Israel Deaconess Medical Center. Analysis of the model under investigation shows that the disease-free equilibrium existing for all parameters is globally asymptotically stable when both [Formula: see text] and [Formula: see text] are less than one. We also carry out the sensitivity analysis to identify the most sensitive parameters for controlling the spread of the infection. Additionally, the solution for the above-mentioned model is obtained by the Laplace-Adomian decomposition method and various simulations are performed by using convenient fractional-order [Formula: see text] .
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spelling pubmed-78802232021-02-16 Fractional methicillin-resistant Staphylococcus aureus infection model under Caputo operator Acay, Bahar Inc, Mustafa Khan, Amir Yusuf, Abdullahi J Appl Math Comput Original Research This study provides a detailed exposition of in-hospital community-acquired methicillin-resistant S. aureus (CA-MRSA) which is a new strain of MRSA, and hospital-acquired methicillin-resistant S. aureus (HA-MRSA) employing Caputo fractional operator. These two strains of MRSA, referred to as staph, have been a serious problem in hospitals and it is known that they give rise to more deaths per year than AIDS. Hence, the transmission dynamics determining whether the CA-MRSA overtakes HA-MRSA is analyzed by means of a non-local fractional derivative. We show the existence and uniqueness of the solutions of the fractional staph infection model through fixed-point theorems. Moreover, stability analysis and iterative solutions are furnished by the recursive procedure. We make use of the parameter values obtained from the Beth Israel Deaconess Medical Center. Analysis of the model under investigation shows that the disease-free equilibrium existing for all parameters is globally asymptotically stable when both [Formula: see text] and [Formula: see text] are less than one. We also carry out the sensitivity analysis to identify the most sensitive parameters for controlling the spread of the infection. Additionally, the solution for the above-mentioned model is obtained by the Laplace-Adomian decomposition method and various simulations are performed by using convenient fractional-order [Formula: see text] . Springer Berlin Heidelberg 2021-02-12 2021 /pmc/articles/PMC7880223/ /pubmed/33613142 http://dx.doi.org/10.1007/s12190-021-01502-3 Text en © Korean Society for Informatics and Computational Applied Mathematics 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Research
Acay, Bahar
Inc, Mustafa
Khan, Amir
Yusuf, Abdullahi
Fractional methicillin-resistant Staphylococcus aureus infection model under Caputo operator
title Fractional methicillin-resistant Staphylococcus aureus infection model under Caputo operator
title_full Fractional methicillin-resistant Staphylococcus aureus infection model under Caputo operator
title_fullStr Fractional methicillin-resistant Staphylococcus aureus infection model under Caputo operator
title_full_unstemmed Fractional methicillin-resistant Staphylococcus aureus infection model under Caputo operator
title_short Fractional methicillin-resistant Staphylococcus aureus infection model under Caputo operator
title_sort fractional methicillin-resistant staphylococcus aureus infection model under caputo operator
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880223/
https://www.ncbi.nlm.nih.gov/pubmed/33613142
http://dx.doi.org/10.1007/s12190-021-01502-3
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