Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir

Coronaviruses use an RNA-dependent RNA polymerase to replicate and transcribe their RNA genome. The structure of the SARS-CoV-2 polymerase was determined by cryo-electron microscopy within a short time in spring 2020. The structure explains how the viral enzyme synthesizes RNA and how it replicates...

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Detalles Bibliográficos
Autores principales: Cramer, Patrick, Kokic, Goran, Dienemann, Christian, Höbartner, Claudia, Hillen, Hauke S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Wissenschaft Special
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880636/
https://www.ncbi.nlm.nih.gov/pubmed/33612990
http://dx.doi.org/10.1007/s12268-021-1516-6
Descripción
Sumario:Coronaviruses use an RNA-dependent RNA polymerase to replicate and transcribe their RNA genome. The structure of the SARS-CoV-2 polymerase was determined by cryo-electron microscopy within a short time in spring 2020. The structure explains how the viral enzyme synthesizes RNA and how it replicates the exceptionally large genome in a processive manner. The most recent structure-function studies further reveal the mechanism of polymerase inhibition by remdesivir, an approved drug for the treatment of COVID-19.

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