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Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success
Triacylglycerol (TG) and steryl ester (SE) lipid storage is a universal strategy to maintain organismal energy and membrane homeostasis. Cycles of building and mobilizing storage fat are fundamental in (re)distributing lipid substrates between tissues or to progress ontogenetic transitions. In this...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880688/ https://www.ncbi.nlm.nih.gov/pubmed/33538247 http://dx.doi.org/10.7554/eLife.63252 |
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author | Heier, Christoph Knittelfelder, Oskar Hofbauer, Harald F Mende, Wolfgang Pörnbacher, Ingrid Schiller, Laura Schoiswohl, Gabriele Xie, Hao Grönke, Sebastian Shevchenko, Andrej Kühnlein, Ronald P |
author_facet | Heier, Christoph Knittelfelder, Oskar Hofbauer, Harald F Mende, Wolfgang Pörnbacher, Ingrid Schiller, Laura Schoiswohl, Gabriele Xie, Hao Grönke, Sebastian Shevchenko, Andrej Kühnlein, Ronald P |
author_sort | Heier, Christoph |
collection | PubMed |
description | Triacylglycerol (TG) and steryl ester (SE) lipid storage is a universal strategy to maintain organismal energy and membrane homeostasis. Cycles of building and mobilizing storage fat are fundamental in (re)distributing lipid substrates between tissues or to progress ontogenetic transitions. In this study, we show that Hormone-sensitive lipase (Hsl) specifically controls SE mobilization to initiate intergenerational sterol transfer in Drosophila melanogaster. Tissue-autonomous Hsl functions in the maternal fat body and germline coordinately prevent adult SE overstorage and maximize sterol allocation to embryos. While Hsl-deficiency is largely dispensable for normal development on sterol-rich diets, animals depend on adipocyte Hsl for optimal fecundity when dietary sterol becomes limiting. Notably, accumulation of SE but not of TG is a characteristic of Hsl-deficient cells across phyla including murine white adipocytes. In summary, we identified Hsl as an ancestral regulator of SE degradation, which improves intergenerational sterol transfer and reproductive success in flies. |
format | Online Article Text |
id | pubmed-7880688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-78806882021-02-16 Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success Heier, Christoph Knittelfelder, Oskar Hofbauer, Harald F Mende, Wolfgang Pörnbacher, Ingrid Schiller, Laura Schoiswohl, Gabriele Xie, Hao Grönke, Sebastian Shevchenko, Andrej Kühnlein, Ronald P eLife Biochemistry and Chemical Biology Triacylglycerol (TG) and steryl ester (SE) lipid storage is a universal strategy to maintain organismal energy and membrane homeostasis. Cycles of building and mobilizing storage fat are fundamental in (re)distributing lipid substrates between tissues or to progress ontogenetic transitions. In this study, we show that Hormone-sensitive lipase (Hsl) specifically controls SE mobilization to initiate intergenerational sterol transfer in Drosophila melanogaster. Tissue-autonomous Hsl functions in the maternal fat body and germline coordinately prevent adult SE overstorage and maximize sterol allocation to embryos. While Hsl-deficiency is largely dispensable for normal development on sterol-rich diets, animals depend on adipocyte Hsl for optimal fecundity when dietary sterol becomes limiting. Notably, accumulation of SE but not of TG is a characteristic of Hsl-deficient cells across phyla including murine white adipocytes. In summary, we identified Hsl as an ancestral regulator of SE degradation, which improves intergenerational sterol transfer and reproductive success in flies. eLife Sciences Publications, Ltd 2021-02-04 /pmc/articles/PMC7880688/ /pubmed/33538247 http://dx.doi.org/10.7554/eLife.63252 Text en © 2021, Heier et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Biochemistry and Chemical Biology Heier, Christoph Knittelfelder, Oskar Hofbauer, Harald F Mende, Wolfgang Pörnbacher, Ingrid Schiller, Laura Schoiswohl, Gabriele Xie, Hao Grönke, Sebastian Shevchenko, Andrej Kühnlein, Ronald P Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success |
title | Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success |
title_full | Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success |
title_fullStr | Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success |
title_full_unstemmed | Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success |
title_short | Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success |
title_sort | hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success |
topic | Biochemistry and Chemical Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880688/ https://www.ncbi.nlm.nih.gov/pubmed/33538247 http://dx.doi.org/10.7554/eLife.63252 |
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