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Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth

Perinatal hypoxia due to obstetric complications has been known to cause neurodevelopmental impairments in infants and children. The severity of the impairments and recovery depends on the degree of hypoxia. There have been some studies which focuses on understanding the effects of perinatal hypoxia...

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Autores principales: Mercogliano, Christina, Poddar, Karuna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880857/
https://www.ncbi.nlm.nih.gov/pubmed/33604219
http://dx.doi.org/10.7759/cureus.12687
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author Mercogliano, Christina
Poddar, Karuna
author_facet Mercogliano, Christina
Poddar, Karuna
author_sort Mercogliano, Christina
collection PubMed
description Perinatal hypoxia due to obstetric complications has been known to cause neurodevelopmental impairments in infants and children. The severity of the impairments and recovery depends on the degree of hypoxia. There have been some studies which focuses on understanding the effects of perinatal hypoxia on cognitive and behavioral functioning like attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disorders, or aggression. Although the studies have investigated the effects in children, there are very few studies done to explore perinatal hypoxia, causing any neuropsychiatric outcomes in adults.  This is a case of a 38-year-old man who presented to psychiatry as a referral for depression by neurology. He saw neurology for intractable migraine resistant to all treatment for the last year. The brain imaging was read as normal with minor small vascular changes. During our assessment, he reported depression and passive suicidal ideation, which began since he was diagnosed with migraines. His developmental history was significant for perinatal asphyxia and learning difficulties. Growing up, he reported severe irritability, impulsivity, and risk-taking behaviors but became stable when he was in his late twenties. His past psychiatric management was unclear. He was seeing an outpatient therapist when he visited our clinic. We diagnosed him with an unspecified mood disorder, tried prozac, and then gabapentin with some effect. Before we could explore further medication trials with topamax, his care had to be transferred to other psychiatrists, and we could not obtain further details of his outcome.  Based on our case, we concluded there is a need for further research focused on the effects of perinatal hypoxia on certain brain areas as a cause of neuropsychiatric symptoms in adults.
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spelling pubmed-78808572021-02-17 Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth Mercogliano, Christina Poddar, Karuna Cureus Psychiatry Perinatal hypoxia due to obstetric complications has been known to cause neurodevelopmental impairments in infants and children. The severity of the impairments and recovery depends on the degree of hypoxia. There have been some studies which focuses on understanding the effects of perinatal hypoxia on cognitive and behavioral functioning like attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disorders, or aggression. Although the studies have investigated the effects in children, there are very few studies done to explore perinatal hypoxia, causing any neuropsychiatric outcomes in adults.  This is a case of a 38-year-old man who presented to psychiatry as a referral for depression by neurology. He saw neurology for intractable migraine resistant to all treatment for the last year. The brain imaging was read as normal with minor small vascular changes. During our assessment, he reported depression and passive suicidal ideation, which began since he was diagnosed with migraines. His developmental history was significant for perinatal asphyxia and learning difficulties. Growing up, he reported severe irritability, impulsivity, and risk-taking behaviors but became stable when he was in his late twenties. His past psychiatric management was unclear. He was seeing an outpatient therapist when he visited our clinic. We diagnosed him with an unspecified mood disorder, tried prozac, and then gabapentin with some effect. Before we could explore further medication trials with topamax, his care had to be transferred to other psychiatrists, and we could not obtain further details of his outcome.  Based on our case, we concluded there is a need for further research focused on the effects of perinatal hypoxia on certain brain areas as a cause of neuropsychiatric symptoms in adults. Cureus 2021-01-13 /pmc/articles/PMC7880857/ /pubmed/33604219 http://dx.doi.org/10.7759/cureus.12687 Text en Copyright © 2021, Mercogliano et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Psychiatry
Mercogliano, Christina
Poddar, Karuna
Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth
title Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth
title_full Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth
title_fullStr Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth
title_full_unstemmed Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth
title_short Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth
title_sort long-term comorbid neuropsychiatric sequelae of hypoxia at birth
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880857/
https://www.ncbi.nlm.nih.gov/pubmed/33604219
http://dx.doi.org/10.7759/cureus.12687
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