Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European ancestry individuals from the Genetic Epidemiology Research on Adult Health and Aging cohort (16,012 cases, 50,552 controls) and UK Biobank (48,969...

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Detalles Bibliográficos
Autores principales: Graff, Rebecca E., Cavazos, Taylor B., Thai, Khanh K., Kachuri, Linda, Rashkin, Sara R., Hoffman, Joshua D., Alexeeff, Stacey E., Blatchins, Maruta, Meyers, Travis J., Leong, Lancelote, Tai, Caroline G., Emami, Nima C., Corley, Douglas A., Kushi, Lawrence H., Ziv, Elad, Van Den Eeden, Stephen K., Jorgenson, Eric, Hoffmann, Thomas J., Habel, Laurel A., Witte, John S., Sakoda, Lori C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880989/
https://www.ncbi.nlm.nih.gov/pubmed/33579919
http://dx.doi.org/10.1038/s41467-021-21288-z

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