Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix

The life cycle of Baculoviridae family insect viruses depends on the viral protein kinase, PK-1, to phosphorylate the regulatory protein, p6.9, to induce baculoviral genome release. Here, we report the crystal structure of Cydia pomenella granulovirus PK-1, which, owing to its likely ancestral origi...

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Detalles Bibliográficos
Autores principales: Oliver, Michael R., Horne, Christopher R., Shrestha, Safal, Keown, Jeremy R., Liang, Lung-Yu, Young, Samuel N., Sandow, Jarrod J., Webb, Andrew I., Goldstone, David C., Lucet, Isabelle S., Kannan, Natarajan, Metcalf, Peter, Murphy, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881018/
https://www.ncbi.nlm.nih.gov/pubmed/33579933
http://dx.doi.org/10.1038/s41467-021-21191-7

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