Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality

Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases associated with various cellular activities) superfamily pr...

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Detalles Bibliográficos
Autores principales: Dafinger, Claudia, Benzing, Thomas, Dötsch, Jörg, Schermer, Bernhard, Liebau, Max C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881068/
https://www.ncbi.nlm.nih.gov/pubmed/33580312
http://dx.doi.org/10.1186/s40348-021-00111-1
Descripción
Sumario:Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases associated with various cellular activities) superfamily protein Ruvbl1 to mammalian epidermal development. Keratinocyte-specific Ruvbl1 knockout mice (Ruvbl1(fl/fl)K14:Cre(tg)) show a severe phenotype including dramatic structural epidermal defects resulting in the loss of the functional skin barrier and perinatal death. Thus, Ruvbl1 is a newly identified essential player for the development of differentiated epidermis in mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40348-021-00111-1.

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