Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality

Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases associated with various cellular activities) superfamily pr...

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Autores principales: Dafinger, Claudia, Benzing, Thomas, Dötsch, Jörg, Schermer, Bernhard, Liebau, Max C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881068/
https://www.ncbi.nlm.nih.gov/pubmed/33580312
http://dx.doi.org/10.1186/s40348-021-00111-1
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author Dafinger, Claudia
Benzing, Thomas
Dötsch, Jörg
Schermer, Bernhard
Liebau, Max C.
author_facet Dafinger, Claudia
Benzing, Thomas
Dötsch, Jörg
Schermer, Bernhard
Liebau, Max C.
author_sort Dafinger, Claudia
collection PubMed
description Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases associated with various cellular activities) superfamily protein Ruvbl1 to mammalian epidermal development. Keratinocyte-specific Ruvbl1 knockout mice (Ruvbl1(fl/fl)K14:Cre(tg)) show a severe phenotype including dramatic structural epidermal defects resulting in the loss of the functional skin barrier and perinatal death. Thus, Ruvbl1 is a newly identified essential player for the development of differentiated epidermis in mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40348-021-00111-1.
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spelling pubmed-78810682021-02-25 Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality Dafinger, Claudia Benzing, Thomas Dötsch, Jörg Schermer, Bernhard Liebau, Max C. Mol Cell Pediatr Short Communication Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases associated with various cellular activities) superfamily protein Ruvbl1 to mammalian epidermal development. Keratinocyte-specific Ruvbl1 knockout mice (Ruvbl1(fl/fl)K14:Cre(tg)) show a severe phenotype including dramatic structural epidermal defects resulting in the loss of the functional skin barrier and perinatal death. Thus, Ruvbl1 is a newly identified essential player for the development of differentiated epidermis in mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40348-021-00111-1. Springer Berlin Heidelberg 2021-02-12 /pmc/articles/PMC7881068/ /pubmed/33580312 http://dx.doi.org/10.1186/s40348-021-00111-1 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Dafinger, Claudia
Benzing, Thomas
Dötsch, Jörg
Schermer, Bernhard
Liebau, Max C.
Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality
title Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality
title_full Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality
title_fullStr Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality
title_full_unstemmed Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality
title_short Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality
title_sort targeted deletion of ruvbl1 results in severe defects of epidermal development and perinatal mortality
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881068/
https://www.ncbi.nlm.nih.gov/pubmed/33580312
http://dx.doi.org/10.1186/s40348-021-00111-1
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