DNA methylation status correlates with adult β-cell regeneration capacity

The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well de...

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Detalles Bibliográficos
Autores principales: Khurana, Ishant, Al-Hasani, Keith, Maxwell, Scott, K.N., Harikrishnan, Okabe, Jun, Cooper, Mark E., Collombat, Patrick, El-Osta, Assam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881134/
https://www.ncbi.nlm.nih.gov/pubmed/33580013
http://dx.doi.org/10.1038/s41536-021-00119-1
Descripción
Sumario:The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.

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