DNA methylation status correlates with adult β-cell regeneration capacity

The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well de...

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Autores principales: Khurana, Ishant, Al-Hasani, Keith, Maxwell, Scott, K.N., Harikrishnan, Okabe, Jun, Cooper, Mark E., Collombat, Patrick, El-Osta, Assam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881134/
https://www.ncbi.nlm.nih.gov/pubmed/33580013
http://dx.doi.org/10.1038/s41536-021-00119-1
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author Khurana, Ishant
Al-Hasani, Keith
Maxwell, Scott
K.N., Harikrishnan
Okabe, Jun
Cooper, Mark E.
Collombat, Patrick
El-Osta, Assam
author_facet Khurana, Ishant
Al-Hasani, Keith
Maxwell, Scott
K.N., Harikrishnan
Okabe, Jun
Cooper, Mark E.
Collombat, Patrick
El-Osta, Assam
author_sort Khurana, Ishant
collection PubMed
description The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.
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spelling pubmed-78811342021-02-25 DNA methylation status correlates with adult β-cell regeneration capacity Khurana, Ishant Al-Hasani, Keith Maxwell, Scott K.N., Harikrishnan Okabe, Jun Cooper, Mark E. Collombat, Patrick El-Osta, Assam NPJ Regen Med Brief Communication The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas. Nature Publishing Group UK 2021-02-12 /pmc/articles/PMC7881134/ /pubmed/33580013 http://dx.doi.org/10.1038/s41536-021-00119-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Khurana, Ishant
Al-Hasani, Keith
Maxwell, Scott
K.N., Harikrishnan
Okabe, Jun
Cooper, Mark E.
Collombat, Patrick
El-Osta, Assam
DNA methylation status correlates with adult β-cell regeneration capacity
title DNA methylation status correlates with adult β-cell regeneration capacity
title_full DNA methylation status correlates with adult β-cell regeneration capacity
title_fullStr DNA methylation status correlates with adult β-cell regeneration capacity
title_full_unstemmed DNA methylation status correlates with adult β-cell regeneration capacity
title_short DNA methylation status correlates with adult β-cell regeneration capacity
title_sort dna methylation status correlates with adult β-cell regeneration capacity
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881134/
https://www.ncbi.nlm.nih.gov/pubmed/33580013
http://dx.doi.org/10.1038/s41536-021-00119-1
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