Cargando…
Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster
To detect the genomic mechanisms underlying evolutionary dynamics of adaptation in sexually reproducing organisms, we analyze multigenerational whole genome sequences of Drosophila melanogaster adapting to extreme O(2) conditions over an experiment conducted for nearly two decades. We develop method...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881140/ https://www.ncbi.nlm.nih.gov/pubmed/33579965 http://dx.doi.org/10.1038/s41467-021-21281-6 |
_version_ | 1783650814037852160 |
---|---|
author | Iranmehr, Arya Stobdan, Tsering Zhou, Dan Zhao, Huiwen Kryazhimskiy, Sergey Bafna, Vineet Haddad, Gabriel G. |
author_facet | Iranmehr, Arya Stobdan, Tsering Zhou, Dan Zhao, Huiwen Kryazhimskiy, Sergey Bafna, Vineet Haddad, Gabriel G. |
author_sort | Iranmehr, Arya |
collection | PubMed |
description | To detect the genomic mechanisms underlying evolutionary dynamics of adaptation in sexually reproducing organisms, we analyze multigenerational whole genome sequences of Drosophila melanogaster adapting to extreme O(2) conditions over an experiment conducted for nearly two decades. We develop methods to analyze time-series genomics data and predict adaptive mechanisms. Here, we report a remarkable level of synchronicity in both hard and soft selective sweeps in replicate populations as well as the arrival of favorable de novo mutations that constitute a few asynchronized sweeps. We additionally make direct experimental observations of rare recombination events that combine multiple alleles on to a single, better-adapted haplotype. Based on the analyses of the genes in genomic intervals, we provide a deeper insight into the mechanisms of genome adaptation that allow complex organisms to survive harsh environments. |
format | Online Article Text |
id | pubmed-7881140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78811402021-02-25 Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster Iranmehr, Arya Stobdan, Tsering Zhou, Dan Zhao, Huiwen Kryazhimskiy, Sergey Bafna, Vineet Haddad, Gabriel G. Nat Commun Article To detect the genomic mechanisms underlying evolutionary dynamics of adaptation in sexually reproducing organisms, we analyze multigenerational whole genome sequences of Drosophila melanogaster adapting to extreme O(2) conditions over an experiment conducted for nearly two decades. We develop methods to analyze time-series genomics data and predict adaptive mechanisms. Here, we report a remarkable level of synchronicity in both hard and soft selective sweeps in replicate populations as well as the arrival of favorable de novo mutations that constitute a few asynchronized sweeps. We additionally make direct experimental observations of rare recombination events that combine multiple alleles on to a single, better-adapted haplotype. Based on the analyses of the genes in genomic intervals, we provide a deeper insight into the mechanisms of genome adaptation that allow complex organisms to survive harsh environments. Nature Publishing Group UK 2021-02-12 /pmc/articles/PMC7881140/ /pubmed/33579965 http://dx.doi.org/10.1038/s41467-021-21281-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Iranmehr, Arya Stobdan, Tsering Zhou, Dan Zhao, Huiwen Kryazhimskiy, Sergey Bafna, Vineet Haddad, Gabriel G. Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster |
title | Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster |
title_full | Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster |
title_fullStr | Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster |
title_full_unstemmed | Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster |
title_short | Multiple mechanisms drive genomic adaptation to extreme O(2) levels in Drosophila melanogaster |
title_sort | multiple mechanisms drive genomic adaptation to extreme o(2) levels in drosophila melanogaster |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881140/ https://www.ncbi.nlm.nih.gov/pubmed/33579965 http://dx.doi.org/10.1038/s41467-021-21281-6 |
work_keys_str_mv | AT iranmehrarya multiplemechanismsdrivegenomicadaptationtoextremeo2levelsindrosophilamelanogaster AT stobdantsering multiplemechanismsdrivegenomicadaptationtoextremeo2levelsindrosophilamelanogaster AT zhoudan multiplemechanismsdrivegenomicadaptationtoextremeo2levelsindrosophilamelanogaster AT zhaohuiwen multiplemechanismsdrivegenomicadaptationtoextremeo2levelsindrosophilamelanogaster AT kryazhimskiysergey multiplemechanismsdrivegenomicadaptationtoextremeo2levelsindrosophilamelanogaster AT bafnavineet multiplemechanismsdrivegenomicadaptationtoextremeo2levelsindrosophilamelanogaster AT haddadgabrielg multiplemechanismsdrivegenomicadaptationtoextremeo2levelsindrosophilamelanogaster |