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Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to c...

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Autores principales: Roychoudhury, Shubhadeep, Das, Anandan, Jha, Niraj Kumar, Kesari, Kavindra Kumar, Roychoudhury, Shatabhisha, Jha, Saurabh Kumar, Kosgi, Raghavender, Choudhury, Arun Paul, Lukac, Norbert, Madhu, Nithar Ranjan, Kumar, Dhruv, Slama, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881178/
https://www.ncbi.nlm.nih.gov/pubmed/33465325
http://dx.doi.org/10.1098/rsob.200347
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author Roychoudhury, Shubhadeep
Das, Anandan
Jha, Niraj Kumar
Kesari, Kavindra Kumar
Roychoudhury, Shatabhisha
Jha, Saurabh Kumar
Kosgi, Raghavender
Choudhury, Arun Paul
Lukac, Norbert
Madhu, Nithar Ranjan
Kumar, Dhruv
Slama, Petr
author_facet Roychoudhury, Shubhadeep
Das, Anandan
Jha, Niraj Kumar
Kesari, Kavindra Kumar
Roychoudhury, Shatabhisha
Jha, Saurabh Kumar
Kosgi, Raghavender
Choudhury, Arun Paul
Lukac, Norbert
Madhu, Nithar Ranjan
Kumar, Dhruv
Slama, Petr
author_sort Roychoudhury, Shubhadeep
collection PubMed
description Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.
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spelling pubmed-78811782021-02-16 Viral pathogenesis of SARS-CoV-2 infection and male reproductive health Roychoudhury, Shubhadeep Das, Anandan Jha, Niraj Kumar Kesari, Kavindra Kumar Roychoudhury, Shatabhisha Jha, Saurabh Kumar Kosgi, Raghavender Choudhury, Arun Paul Lukac, Norbert Madhu, Nithar Ranjan Kumar, Dhruv Slama, Petr Open Biol Review Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted. The Royal Society 2021-01-20 /pmc/articles/PMC7881178/ /pubmed/33465325 http://dx.doi.org/10.1098/rsob.200347 Text en © 2021 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Roychoudhury, Shubhadeep
Das, Anandan
Jha, Niraj Kumar
Kesari, Kavindra Kumar
Roychoudhury, Shatabhisha
Jha, Saurabh Kumar
Kosgi, Raghavender
Choudhury, Arun Paul
Lukac, Norbert
Madhu, Nithar Ranjan
Kumar, Dhruv
Slama, Petr
Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
title Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
title_full Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
title_fullStr Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
title_full_unstemmed Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
title_short Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
title_sort viral pathogenesis of sars-cov-2 infection and male reproductive health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881178/
https://www.ncbi.nlm.nih.gov/pubmed/33465325
http://dx.doi.org/10.1098/rsob.200347
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