Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer

Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-li...

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Autores principales: Griguolo, Gaia, Dieci, Maria Vittoria, Paré, Laia, Miglietta, Federica, Generali, Daniele Giulio, Frassoldati, Antonio, Cavanna, Luigi, Bisagni, Giancarlo, Piacentini, Federico, Tagliafico, Enrico, Cagossi, Katia, Ficarra, Guido, Prat, Aleix, Conte, Pierfranco, Guarneri, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881184/
https://www.ncbi.nlm.nih.gov/pubmed/33579951
http://dx.doi.org/10.1038/s41523-021-00223-x
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author Griguolo, Gaia
Dieci, Maria Vittoria
Paré, Laia
Miglietta, Federica
Generali, Daniele Giulio
Frassoldati, Antonio
Cavanna, Luigi
Bisagni, Giancarlo
Piacentini, Federico
Tagliafico, Enrico
Cagossi, Katia
Ficarra, Guido
Prat, Aleix
Conte, Pierfranco
Guarneri, Valentina
author_facet Griguolo, Gaia
Dieci, Maria Vittoria
Paré, Laia
Miglietta, Federica
Generali, Daniele Giulio
Frassoldati, Antonio
Cavanna, Luigi
Bisagni, Giancarlo
Piacentini, Federico
Tagliafico, Enrico
Cagossi, Katia
Ficarra, Guido
Prat, Aleix
Conte, Pierfranco
Guarneri, Valentina
author_sort Griguolo, Gaia
collection PubMed
description Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocyte levels than luminal tumors. Moreover, significant differences in immune infiltrate composition, assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatory antitumor immune infiltrate composition than luminal ones.
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spelling pubmed-78811842021-02-25 Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer Griguolo, Gaia Dieci, Maria Vittoria Paré, Laia Miglietta, Federica Generali, Daniele Giulio Frassoldati, Antonio Cavanna, Luigi Bisagni, Giancarlo Piacentini, Federico Tagliafico, Enrico Cagossi, Katia Ficarra, Guido Prat, Aleix Conte, Pierfranco Guarneri, Valentina NPJ Breast Cancer Brief Communication Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocyte levels than luminal tumors. Moreover, significant differences in immune infiltrate composition, assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatory antitumor immune infiltrate composition than luminal ones. Nature Publishing Group UK 2021-02-12 /pmc/articles/PMC7881184/ /pubmed/33579951 http://dx.doi.org/10.1038/s41523-021-00223-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Griguolo, Gaia
Dieci, Maria Vittoria
Paré, Laia
Miglietta, Federica
Generali, Daniele Giulio
Frassoldati, Antonio
Cavanna, Luigi
Bisagni, Giancarlo
Piacentini, Federico
Tagliafico, Enrico
Cagossi, Katia
Ficarra, Guido
Prat, Aleix
Conte, Pierfranco
Guarneri, Valentina
Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_full Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_fullStr Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_full_unstemmed Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_short Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer
title_sort immune microenvironment and intrinsic subtyping in hormone receptor-positive/her2-negative breast cancer
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881184/
https://www.ncbi.nlm.nih.gov/pubmed/33579951
http://dx.doi.org/10.1038/s41523-021-00223-x
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