Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis

Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activi...

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Autores principales: Hachiya, Tsuyoshi, Kobayashi, Takuro, Tsutae, Wataru, Gan, Pamela Hui Peng, Baran, Iri Sato, Horie, Shigeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881200/
https://www.ncbi.nlm.nih.gov/pubmed/33580176
http://dx.doi.org/10.1038/s41598-021-83308-8
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author Hachiya, Tsuyoshi
Kobayashi, Takuro
Tsutae, Wataru
Gan, Pamela Hui Peng
Baran, Iri Sato
Horie, Shigeo
author_facet Hachiya, Tsuyoshi
Kobayashi, Takuro
Tsutae, Wataru
Gan, Pamela Hui Peng
Baran, Iri Sato
Horie, Shigeo
author_sort Hachiya, Tsuyoshi
collection PubMed
description Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activity, but not with smoking. While these data support the robust association between saliva-derived mLOY and aging, caution is required when comparing data from saliva-derived and blood-derived mLOY.
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spelling pubmed-78812002021-02-16 Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis Hachiya, Tsuyoshi Kobayashi, Takuro Tsutae, Wataru Gan, Pamela Hui Peng Baran, Iri Sato Horie, Shigeo Sci Rep Article Mosaic loss of chromosome Y (mLOY) in leukocytes has attracted much attention as an emerging biomarker of aging and aging-related diseases. We evaluated the usefulness of saliva for mLOY analysis and showed that saliva-derived mLOY is significantly associated with aging and increased physical activity, but not with smoking. While these data support the robust association between saliva-derived mLOY and aging, caution is required when comparing data from saliva-derived and blood-derived mLOY. Nature Publishing Group UK 2021-02-12 /pmc/articles/PMC7881200/ /pubmed/33580176 http://dx.doi.org/10.1038/s41598-021-83308-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hachiya, Tsuyoshi
Kobayashi, Takuro
Tsutae, Wataru
Gan, Pamela Hui Peng
Baran, Iri Sato
Horie, Shigeo
Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_full Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_fullStr Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_full_unstemmed Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_short Evaluation of the usefulness of saliva for mosaic loss of chromosome Y analysis
title_sort evaluation of the usefulness of saliva for mosaic loss of chromosome y analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881200/
https://www.ncbi.nlm.nih.gov/pubmed/33580176
http://dx.doi.org/10.1038/s41598-021-83308-8
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