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Homologous laminar organization of the mouse and human subiculum
The subiculum is the major output component of the hippocampal formation and one of the major brain structures most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within the mouse subiculum. However, the rotation of the hippocampal longitudinal axis across...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881248/ https://www.ncbi.nlm.nih.gov/pubmed/33580088 http://dx.doi.org/10.1038/s41598-021-81362-w |
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author | Bienkowski, Michael S. Sepehrband, Farshid Kurniawan, Nyoman D. Stanis, Jim Korobkova, Laura Khanjani, Neda Clark, Kristi Hintiryan, Houri Miller, Carol A. Dong, Hong-Wei |
author_facet | Bienkowski, Michael S. Sepehrband, Farshid Kurniawan, Nyoman D. Stanis, Jim Korobkova, Laura Khanjani, Neda Clark, Kristi Hintiryan, Houri Miller, Carol A. Dong, Hong-Wei |
author_sort | Bienkowski, Michael S. |
collection | PubMed |
description | The subiculum is the major output component of the hippocampal formation and one of the major brain structures most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within the mouse subiculum. However, the rotation of the hippocampal longitudinal axis across species makes it unclear how the laminar organization is represented in human subiculum. Using in situ hybridization data from the Allen Human Brain Atlas, we demonstrate that the human subiculum also contains complementary laminar gene expression patterns similar to the mouse. In addition, we provide evidence that the molecular domain boundaries in human subiculum correspond to microstructural differences observed in high resolution MRI and fiber density imaging. Finally, we show both similarities and differences in the gene expression profile of subiculum pyramidal cells within homologous lamina. Overall, we present a new 3D model of the anatomical organization of human subiculum and its evolution from the mouse. |
format | Online Article Text |
id | pubmed-7881248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78812482021-02-16 Homologous laminar organization of the mouse and human subiculum Bienkowski, Michael S. Sepehrband, Farshid Kurniawan, Nyoman D. Stanis, Jim Korobkova, Laura Khanjani, Neda Clark, Kristi Hintiryan, Houri Miller, Carol A. Dong, Hong-Wei Sci Rep Article The subiculum is the major output component of the hippocampal formation and one of the major brain structures most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within the mouse subiculum. However, the rotation of the hippocampal longitudinal axis across species makes it unclear how the laminar organization is represented in human subiculum. Using in situ hybridization data from the Allen Human Brain Atlas, we demonstrate that the human subiculum also contains complementary laminar gene expression patterns similar to the mouse. In addition, we provide evidence that the molecular domain boundaries in human subiculum correspond to microstructural differences observed in high resolution MRI and fiber density imaging. Finally, we show both similarities and differences in the gene expression profile of subiculum pyramidal cells within homologous lamina. Overall, we present a new 3D model of the anatomical organization of human subiculum and its evolution from the mouse. Nature Publishing Group UK 2021-02-12 /pmc/articles/PMC7881248/ /pubmed/33580088 http://dx.doi.org/10.1038/s41598-021-81362-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bienkowski, Michael S. Sepehrband, Farshid Kurniawan, Nyoman D. Stanis, Jim Korobkova, Laura Khanjani, Neda Clark, Kristi Hintiryan, Houri Miller, Carol A. Dong, Hong-Wei Homologous laminar organization of the mouse and human subiculum |
title | Homologous laminar organization of the mouse and human subiculum |
title_full | Homologous laminar organization of the mouse and human subiculum |
title_fullStr | Homologous laminar organization of the mouse and human subiculum |
title_full_unstemmed | Homologous laminar organization of the mouse and human subiculum |
title_short | Homologous laminar organization of the mouse and human subiculum |
title_sort | homologous laminar organization of the mouse and human subiculum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881248/ https://www.ncbi.nlm.nih.gov/pubmed/33580088 http://dx.doi.org/10.1038/s41598-021-81362-w |
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