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The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis

OBJECTIVE: Recent studies have implicated increased oxidative stress in the pathogenesis of Ankylosing spondylitis (AS). Ischemia-modified albumin (IMA), an altered form of albumin, increases oxidative stress. This study aimed to investigate the relationship between IMA levels and other indicators o...

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Autores principales: Sertpoyraz, Filiz Meryem, Colak, Ayfer, Dikici, Aylin, Gunduz, Nihan Erdinc, Aksit, Merve Zeytinli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881419/
https://www.ncbi.nlm.nih.gov/pubmed/33623872
http://dx.doi.org/10.14744/nci.2020.23590
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author Sertpoyraz, Filiz Meryem
Colak, Ayfer
Dikici, Aylin
Gunduz, Nihan Erdinc
Aksit, Merve Zeytinli
author_facet Sertpoyraz, Filiz Meryem
Colak, Ayfer
Dikici, Aylin
Gunduz, Nihan Erdinc
Aksit, Merve Zeytinli
author_sort Sertpoyraz, Filiz Meryem
collection PubMed
description OBJECTIVE: Recent studies have implicated increased oxidative stress in the pathogenesis of Ankylosing spondylitis (AS). Ischemia-modified albumin (IMA), an altered form of albumin, increases oxidative stress. This study aimed to investigate the relationship between IMA levels and other indicators of disease severity in AS. METHODS: This study included 63 AS patients and 48 healthy controls. Patients were examined for serum lipid profile, C-reactive protein (CRP), complete blood count, Bath Ankylosing Spondylitis Disease Activity Index, human leukocyte antigen (HLA) B27, and treatment regimen. They were categorized based on disease activity, HLA-B27 status, and the drug treatment and compared for IMA levels. RESULTS: The patients had significantly higher IMA levels than controls (p=0.020); among patients, the levels were higher in those with active disease (p=0.001) and positively correlated with the CRP levels. No significant difference was found between the IMA levels of the patients with different HLA-B27 status or treatment method. CONCLUSION: The IMA levels were higher in patients than controls and further increased in patients with active AS. IMA was associated with disease activity and can be used as an inflammatory marker in AS. More comprehensive future studies with a larger sample size may help understand the relationship in greater detail.
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spelling pubmed-78814192021-02-22 The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis Sertpoyraz, Filiz Meryem Colak, Ayfer Dikici, Aylin Gunduz, Nihan Erdinc Aksit, Merve Zeytinli North Clin Istanb Original Article OBJECTIVE: Recent studies have implicated increased oxidative stress in the pathogenesis of Ankylosing spondylitis (AS). Ischemia-modified albumin (IMA), an altered form of albumin, increases oxidative stress. This study aimed to investigate the relationship between IMA levels and other indicators of disease severity in AS. METHODS: This study included 63 AS patients and 48 healthy controls. Patients were examined for serum lipid profile, C-reactive protein (CRP), complete blood count, Bath Ankylosing Spondylitis Disease Activity Index, human leukocyte antigen (HLA) B27, and treatment regimen. They were categorized based on disease activity, HLA-B27 status, and the drug treatment and compared for IMA levels. RESULTS: The patients had significantly higher IMA levels than controls (p=0.020); among patients, the levels were higher in those with active disease (p=0.001) and positively correlated with the CRP levels. No significant difference was found between the IMA levels of the patients with different HLA-B27 status or treatment method. CONCLUSION: The IMA levels were higher in patients than controls and further increased in patients with active AS. IMA was associated with disease activity and can be used as an inflammatory marker in AS. More comprehensive future studies with a larger sample size may help understand the relationship in greater detail. Kare Publishing 2020-11-24 /pmc/articles/PMC7881419/ /pubmed/33623872 http://dx.doi.org/10.14744/nci.2020.23590 Text en Copyright: © 2021 by Istanbul Northern Anatolian Association of Public Hospitals http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Article
Sertpoyraz, Filiz Meryem
Colak, Ayfer
Dikici, Aylin
Gunduz, Nihan Erdinc
Aksit, Merve Zeytinli
The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis
title The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis
title_full The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis
title_fullStr The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis
title_full_unstemmed The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis
title_short The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis
title_sort relationship of ischemia-modified albumin levels to disease activity scores and hla-b27 in patients with ankylosing spondylitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881419/
https://www.ncbi.nlm.nih.gov/pubmed/33623872
http://dx.doi.org/10.14744/nci.2020.23590
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