5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells

BACKGROUND: Glycosylation, one of the most fundamental post-translational modifications, is altered in cancer and is subject in part, to epigenetic regulation. As there are many epigenetic-targeted therapies currently in clinical trials for the treatment of a variety of cancers, it is important to u...

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Detalles Bibliográficos
Autores principales: Greville, Gordon, Llop, Esther, Howard, Jane, Madden, Stephen F., Perry, Antoinette S., Peracaula, Rosa, Rudd, Pauline M., McCann, Amanda, Saldova, Radka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881483/
https://www.ncbi.nlm.nih.gov/pubmed/33579350
http://dx.doi.org/10.1186/s13148-021-01015-7

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