AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts

BACKGROUND: Little is known on the role of transient receptor potential ankyrin 1 (TRPA1) in fibroblast—myofibroblast transition (FMT) that can lead to airway remodeling which is a major problem for severe asthma and fibrosis. Thus, this study investigated the effect of TRPA1 modulators on transform...

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Detalles Bibliográficos
Autores principales: Yap, Jennifer Maries Go, Ueda, Takashi, Kanemitsu, Yoshihiro, Takeda, Norihisa, Fukumitsu, Kensuke, Fukuda, Satoshi, Uemura, Takehiro, Tajiri, Tomoko, Ohkubo, Hirotsugu, Maeno, Ken, Ito, Yutaka, Oguri, Testsuya, Ugawa, Shinya, Niimi, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881560/
https://www.ncbi.nlm.nih.gov/pubmed/33579280
http://dx.doi.org/10.1186/s12931-021-01636-9

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