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Effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics

BACKGROUND: Major Depressive Disorder (MDD) is a disabling mood disorder, profoundly affecting a large number of adolescent’s quality of life. To date, no obvious treatment of choice for MDD in adolescents is available and progress in the treatment of depressed adolescents will have important public...

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Autores principales: Waraan, Luxsiya, Rognli, Erling W., Czajkowski, Nikolai Olavi, Aalberg, Marianne, Mehlum, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881666/
https://www.ncbi.nlm.nih.gov/pubmed/33579332
http://dx.doi.org/10.1186/s13034-021-00361-x
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author Waraan, Luxsiya
Rognli, Erling W.
Czajkowski, Nikolai Olavi
Aalberg, Marianne
Mehlum, Lars
author_facet Waraan, Luxsiya
Rognli, Erling W.
Czajkowski, Nikolai Olavi
Aalberg, Marianne
Mehlum, Lars
author_sort Waraan, Luxsiya
collection PubMed
description BACKGROUND: Major Depressive Disorder (MDD) is a disabling mood disorder, profoundly affecting a large number of adolescent’s quality of life. To date, no obvious treatment of choice for MDD in adolescents is available and progress in the treatment of depressed adolescents will have important public health implications. Attachment-Based Family Therapy (ABFT), as the only empirically supported family therapy model designed to treat adolescent depression, aims to repair interpersonal ruptures and rebuild an emotionally protective parent–child relationship. OBJECTIVE: To study the effectiveness of ABFT compared with treatment as usual (TAU) delivered within child- and adolescent mental health services (CAMHS) to adolescents with MDD. METHOD: Sixty adolescents (86.7% girls), aged 13–18 years (M = 14.9, SD = 1.35), with MDD referred to two CAMHS were randomized to 16 weeks of ABFT or TAU. ABFT consisted of weekly therapy sessions (family/individual or both) according to the treatment manual. TAU was not monitored. Primary outcomes were assessed by blinded evaluators at baseline and post-treatment with the Hamilton Depression Scale (HAMD). Self-reported (Beck Depression Inventory-II, BDI-II) depressive symptoms were assessed at baseline, and after 4, 6, 8, 10,12, 14, and 16 weeks. Analyses were performed according to intent-to-treat principles. RESULTS: At post-treatment, clinician-rated remission rates on the HAMD (5% in ABFT and 3.33% in TAU, p = 1, OR = 1.54, Fisher’s exact test) and self-reported symptoms of depression on the BDI-II did not differ significantly between groups (X(2)[2, N = 60] = 0.06, p = 0.97). In both treatment groups participants reported significantly reduced depressive symptoms, but the majority (63.3%) of adolescents were still in the clinical range after 16 weeks of treatment. CONCLUSION: ABFT was not superior to TAU. Remission and response rates were low in both groups, suggesting none of the treatments were effective in treating MDD in adolescents. Findings must be viewed in the context of the study’s small sample size, missing data, and implementation challenges. Continued efforts to improve treatment for MDD in outpatient clinics are warranted. Future research should examine moderators of and mechanisms for individual differences to treatment response, as well as the feasibility and cost-effectiveness of implementing treatment models which may require extensive training and expertise to yield clinically meaningful improvements in non-research settings. Trial registration Clinicaltrials.gov identifier: NCT01830088 https://clinicaltrials.gov/ct2/show/NCT01830088?term=Villab%C3%B8&draw=2&rank=1 Date of registration: April 12, 2013
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spelling pubmed-78816662021-02-17 Effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics Waraan, Luxsiya Rognli, Erling W. Czajkowski, Nikolai Olavi Aalberg, Marianne Mehlum, Lars Child Adolesc Psychiatry Ment Health Research Article BACKGROUND: Major Depressive Disorder (MDD) is a disabling mood disorder, profoundly affecting a large number of adolescent’s quality of life. To date, no obvious treatment of choice for MDD in adolescents is available and progress in the treatment of depressed adolescents will have important public health implications. Attachment-Based Family Therapy (ABFT), as the only empirically supported family therapy model designed to treat adolescent depression, aims to repair interpersonal ruptures and rebuild an emotionally protective parent–child relationship. OBJECTIVE: To study the effectiveness of ABFT compared with treatment as usual (TAU) delivered within child- and adolescent mental health services (CAMHS) to adolescents with MDD. METHOD: Sixty adolescents (86.7% girls), aged 13–18 years (M = 14.9, SD = 1.35), with MDD referred to two CAMHS were randomized to 16 weeks of ABFT or TAU. ABFT consisted of weekly therapy sessions (family/individual or both) according to the treatment manual. TAU was not monitored. Primary outcomes were assessed by blinded evaluators at baseline and post-treatment with the Hamilton Depression Scale (HAMD). Self-reported (Beck Depression Inventory-II, BDI-II) depressive symptoms were assessed at baseline, and after 4, 6, 8, 10,12, 14, and 16 weeks. Analyses were performed according to intent-to-treat principles. RESULTS: At post-treatment, clinician-rated remission rates on the HAMD (5% in ABFT and 3.33% in TAU, p = 1, OR = 1.54, Fisher’s exact test) and self-reported symptoms of depression on the BDI-II did not differ significantly between groups (X(2)[2, N = 60] = 0.06, p = 0.97). In both treatment groups participants reported significantly reduced depressive symptoms, but the majority (63.3%) of adolescents were still in the clinical range after 16 weeks of treatment. CONCLUSION: ABFT was not superior to TAU. Remission and response rates were low in both groups, suggesting none of the treatments were effective in treating MDD in adolescents. Findings must be viewed in the context of the study’s small sample size, missing data, and implementation challenges. Continued efforts to improve treatment for MDD in outpatient clinics are warranted. Future research should examine moderators of and mechanisms for individual differences to treatment response, as well as the feasibility and cost-effectiveness of implementing treatment models which may require extensive training and expertise to yield clinically meaningful improvements in non-research settings. Trial registration Clinicaltrials.gov identifier: NCT01830088 https://clinicaltrials.gov/ct2/show/NCT01830088?term=Villab%C3%B8&draw=2&rank=1 Date of registration: April 12, 2013 BioMed Central 2021-02-12 /pmc/articles/PMC7881666/ /pubmed/33579332 http://dx.doi.org/10.1186/s13034-021-00361-x Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Waraan, Luxsiya
Rognli, Erling W.
Czajkowski, Nikolai Olavi
Aalberg, Marianne
Mehlum, Lars
Effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics
title Effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics
title_full Effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics
title_fullStr Effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics
title_full_unstemmed Effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics
title_short Effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics
title_sort effectiveness of attachment-based family therapy compared to treatment as usual for depressed adolescents in community mental health clinics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881666/
https://www.ncbi.nlm.nih.gov/pubmed/33579332
http://dx.doi.org/10.1186/s13034-021-00361-x
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