“Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture

The study of humans with genetic mutations which lead to a substantial disturbance of physiological processes has made a contribution to biomedical science that is disproportionate to the rarity of affected individuals. In this lecture, I discuss examples of where such studies have helped to illumin...

Descripción completa

Detalles Bibliográficos
Autor principal: O’Rahilly, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
ADA Award Lectures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881844/
https://www.ncbi.nlm.nih.gov/pubmed/33355307
http://dx.doi.org/10.2337/dbi19-0037
_version_ 1783650959404040192
author O’Rahilly, Stephen
author_facet O’Rahilly, Stephen
author_sort O’Rahilly, Stephen
collection PubMed
description The study of humans with genetic mutations which lead to a substantial disturbance of physiological processes has made a contribution to biomedical science that is disproportionate to the rarity of affected individuals. In this lecture, I discuss examples of where such studies have helped to illuminate two areas of human metabolism. First, the control of insulin sensitivity and its disruption in states of insulin resistance and second, the regulation of energy balance and its disturbances in obesity.
format Online
Article
Text
id pubmed-7881844
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-78818442021-02-22 “Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture O’Rahilly, Stephen Diabetes ADA Award Lectures The study of humans with genetic mutations which lead to a substantial disturbance of physiological processes has made a contribution to biomedical science that is disproportionate to the rarity of affected individuals. In this lecture, I discuss examples of where such studies have helped to illuminate two areas of human metabolism. First, the control of insulin sensitivity and its disruption in states of insulin resistance and second, the regulation of energy balance and its disturbances in obesity. American Diabetes Association 2021-01 2020-12-15 /pmc/articles/PMC7881844/ /pubmed/33355307 http://dx.doi.org/10.2337/dbi19-0037 Text en © 2020 by the American Diabetes Association https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.
spellingShingle ADA Award Lectures
O’Rahilly, Stephen
“Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture
title “Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture
title_full “Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture
title_fullStr “Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture
title_full_unstemmed “Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture
title_short “Treasure Your Exceptions”—Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture
title_sort “treasure your exceptions”—studying human extreme phenotypes to illuminate metabolic health and disease: the 2019 banting medal for scientific achievement lecture
topic ADA Award Lectures
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881844/
https://www.ncbi.nlm.nih.gov/pubmed/33355307
http://dx.doi.org/10.2337/dbi19-0037
work_keys_str_mv AT orahillystephen treasureyourexceptionsstudyinghumanextremephenotypestoilluminatemetabolichealthanddiseasethe2019bantingmedalforscientificachievementlecture

Ejemplares similares