Pancreatic β-Cell–Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion

Insulin secretory granules (SGs) mediate the regulated secretion of insulin, which is essential for glucose homeostasis. The basic machinery responsible for this regulated exocytosis consists of specific proteins present both at the plasma membrane and on insulin SGs. The protein composition of insu...

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Detalles Bibliográficos
Autores principales: Burns, Christian H., Yau, Belinda, Rodriguez, Anjelica, Triplett, Jenna, Maslar, Drew, An, You Sun, van der Welle, Reini E.N., Kossina, Ross G., Fisher, Max R., Strout, Gregory W., Bayguinov, Peter O., Veenendaal, Tineke, Chitayat, David, Fitzpatrick, James A.J., Klumperman, Judith, Kebede, Melkam A., Asensio, Cedric S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881869/
https://www.ncbi.nlm.nih.gov/pubmed/33168621
http://dx.doi.org/10.2337/db20-0454

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