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Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study

We investigated how baseline values and rates of decline in components of sarcopenia and other body composition parameters relate to adverse clinical outcomes using the Health, Aging, and Body Composition Study. 2689 participants aged 70–79 years were studied. Appendicular lean mass, whole body fat...

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Autores principales: Westbury, Leo D., Syddall, Holly E., Fuggle, Nicholas R., Dennison, Elaine M., Harvey, Nicholas C., Cauley, Jane A., Shiroma, Eric J., Fielding, Roger A., Newman, Anne B., Cooper, Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881954/
https://www.ncbi.nlm.nih.gov/pubmed/33191483
http://dx.doi.org/10.1007/s00223-020-00775-3
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author Westbury, Leo D.
Syddall, Holly E.
Fuggle, Nicholas R.
Dennison, Elaine M.
Harvey, Nicholas C.
Cauley, Jane A.
Shiroma, Eric J.
Fielding, Roger A.
Newman, Anne B.
Cooper, Cyrus
author_facet Westbury, Leo D.
Syddall, Holly E.
Fuggle, Nicholas R.
Dennison, Elaine M.
Harvey, Nicholas C.
Cauley, Jane A.
Shiroma, Eric J.
Fielding, Roger A.
Newman, Anne B.
Cooper, Cyrus
author_sort Westbury, Leo D.
collection PubMed
description We investigated how baseline values and rates of decline in components of sarcopenia and other body composition parameters relate to adverse clinical outcomes using the Health, Aging, and Body Composition Study. 2689 participants aged 70–79 years were studied. Appendicular lean mass, whole body fat mass, and total hip BMD were ascertained using DXA; muscle strength by grip dynamometry; and muscle function by gait speed. Baseline values and 2–3 year conditional changes (independent of baseline) in each characteristic were examined as predictors of mortality, hospital admission, low trauma fracture, and recurrent falls in the subsequent 10–14 years using Cox regression (generalized estimating equations used for recurrent falls) with adjustment for sex, ethnicity, age, and potential confounders. Lower levels and greater declines in all parameters (excluding hip BMD level) were associated (p < 0.05) with increased rates of mortality; fully-adjusted hazard ratios per SD lower gait speed and grip strength were 1.27 (95% CI 1.19, 1.36) and 1.14 (1.07, 1.21), respectively. Risk factors of hospital admission included lower levels and greater declines in gait speed and grip strength, and greater declines in hip BMD. Lower levels and greater declines in fat mass and hip BMD were associated with low trauma fracture. Lower gait speed, higher fat mass, and both lower levels and greater declines in grip strength were related to recurrent falls. Lower baseline levels and greater declines in musculoskeletal parameters were related to adverse outcomes. Interventions to maximize peak levels in earlier life and reduce rates of age-related decline may reduce the burden of disease in this age group. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00223-020-00775-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-78819542021-02-25 Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study Westbury, Leo D. Syddall, Holly E. Fuggle, Nicholas R. Dennison, Elaine M. Harvey, Nicholas C. Cauley, Jane A. Shiroma, Eric J. Fielding, Roger A. Newman, Anne B. Cooper, Cyrus Calcif Tissue Int Original Research We investigated how baseline values and rates of decline in components of sarcopenia and other body composition parameters relate to adverse clinical outcomes using the Health, Aging, and Body Composition Study. 2689 participants aged 70–79 years were studied. Appendicular lean mass, whole body fat mass, and total hip BMD were ascertained using DXA; muscle strength by grip dynamometry; and muscle function by gait speed. Baseline values and 2–3 year conditional changes (independent of baseline) in each characteristic were examined as predictors of mortality, hospital admission, low trauma fracture, and recurrent falls in the subsequent 10–14 years using Cox regression (generalized estimating equations used for recurrent falls) with adjustment for sex, ethnicity, age, and potential confounders. Lower levels and greater declines in all parameters (excluding hip BMD level) were associated (p < 0.05) with increased rates of mortality; fully-adjusted hazard ratios per SD lower gait speed and grip strength were 1.27 (95% CI 1.19, 1.36) and 1.14 (1.07, 1.21), respectively. Risk factors of hospital admission included lower levels and greater declines in gait speed and grip strength, and greater declines in hip BMD. Lower levels and greater declines in fat mass and hip BMD were associated with low trauma fracture. Lower gait speed, higher fat mass, and both lower levels and greater declines in grip strength were related to recurrent falls. Lower baseline levels and greater declines in musculoskeletal parameters were related to adverse outcomes. Interventions to maximize peak levels in earlier life and reduce rates of age-related decline may reduce the burden of disease in this age group. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00223-020-00775-3) contains supplementary material, which is available to authorized users. Springer US 2020-11-15 2021 /pmc/articles/PMC7881954/ /pubmed/33191483 http://dx.doi.org/10.1007/s00223-020-00775-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Research
Westbury, Leo D.
Syddall, Holly E.
Fuggle, Nicholas R.
Dennison, Elaine M.
Harvey, Nicholas C.
Cauley, Jane A.
Shiroma, Eric J.
Fielding, Roger A.
Newman, Anne B.
Cooper, Cyrus
Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study
title Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study
title_full Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study
title_fullStr Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study
title_full_unstemmed Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study
title_short Relationships Between Level and Change in Sarcopenia and Other Body Composition Components and Adverse Health Outcomes: Findings from the Health, Aging, and Body Composition Study
title_sort relationships between level and change in sarcopenia and other body composition components and adverse health outcomes: findings from the health, aging, and body composition study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881954/
https://www.ncbi.nlm.nih.gov/pubmed/33191483
http://dx.doi.org/10.1007/s00223-020-00775-3
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